AG-18 - CAS 118409-57-7
Catalog number: B0084-161623
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C10H6N2O2
Molecular Weight:
186.17
COA:
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Targets:
EGFR
Description:
AG 18 (10 μM) inhibits EGF-induced proliferation of GH3 cells.
Purity:
>98%
Synonyms:
RG-50810, Tyrphostin A23
MSDS:
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InChIKey:
VTJXFTPMFYAJJU-UHFFFAOYSA-N
InChI:
InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
Canonical SMILES:
C1=CC(=C(C=C1C=C(C#N)C#N)O)O
1.Severe and contrasted polymetallic contamination patterns (1900-2009) in the Loire River sediments (France).
Grosbois C1, Meybeck M, Lestel L, Lefèvre I, Moatar F. Sci Total Environ. 2012 Oct 1;435-436:290-305. doi: 10.1016/j.scitotenv.2012.06.056. Epub 2012 Aug 2.
The Loire River basin (117,800 km(2), France) has been exposed to multiple sources of metals during the last 150 years, originating from major mining districts (coal and non-ferrous metals) and their associated industrial activities. Geochemical archives are established here from the analysis of a 4m sediment core in the downstream floodplain and then compared to stream bed sediments from pristine monolithological sub-basins and from bed and bank sediments in impacted tributaries. The contamination is assessed for 55 major and trace elements through their enrichment factors to Al (EF), normalized to the pre-anthropogenic background. Archives from 1900 to 2009 show enrichment (EF<1.3) not only for Ba, Be, Cs, Ga, Rb, REE, Sr, V, and Zr but also for U and Th, despite U mining activities until the 1990s. From 1900 to 1950, the level of contamination is severe for Hg, Au, Ag (10<EF<30), important for Sb and Sn (3<EF<7) and moderate for Cu, Pb and Zn (1.
2.A precise hexagonal octadecanuclear Ag macrocycle with significant luminescent properties.
Jin J1, Wang W, Liu Y, Hou H, Fan Y. Chem Commun (Camb). 2011 Jul 14;47(26):7461-3. doi: 10.1039/c1cc12142a. Epub 2011 May 31.
The first hexagonal octadecanuclear Ag macrocycle [Ag(18)(TTTMB)(12)](NO(3))(18)·30H(2)O has been hydrothermally synthesized. The outside and inner diameters of the unprecedented architecture are about 27.72(13) Å and 15.37(7) Å, respectively. This complex displays a huge increase in the intensity and lifetime of phosphorescence with decreasing temperature.
3.Effects of tyrosine kinase and phosphatase inhibitors on mitosis progression in synchronized tobacco BY-2 cells.
Sheremet YA1, Yemets AI, Azmi A, Vissenberg K, Verbelen JP, Blume YB. Tsitol Genet. 2012 Sep-Oct;46(5):3-11.
To test whether reversible tubulin phosphorylation plays any role in the process of plant mitosis the effects of inhibitors of tyrosine kinases, herbimycin A, genistein and tyrphostin AG 18, and of an inhibitor of tyrosine phosphatases, sodium orthovanadate, on microtubule organization and mitosis progression in a synchronized BY-2 culture has been investigated. It was found that treatment with inhibitors of tyrosine kinases of BY-2 cells at the G2/M transition did not lead to visible disturbances of mitotic microtubule structures, while it did reduce the frequency of their appearance. We assume that a decreased tyrosine phosphorylation level could alter the microtubule dynamic instability parameters during interphase/prophase transition. All types of tyrosine kinase inhibitors used caused a prophase delay: herbimycin A and genistein for 2 h, and tyrphostin AG18 for 1 h. Thereafter the peak of mitosis was displaced for 1 h by herbimycin A or genistein exposure, but after tyrphostin AG18 treatment the timing of the mitosis-peak was comparable to that in control cells.
4.Increased amounts of von Willebrand factor are bound to microparticles after infusion of desmopressin.
Trummer A1, Haarmeijer B, Werwitzke S, Wermes C, Ganser A, Budde U, Tiede A. Haemophilia. 2013 Mar;19(2):236-41. doi: 10.1111/hae.12032. Epub 2012 Oct 11.
Effects of desmopressin (DDAVP) in platelet disorders and primary haemostasis cannot be attributed solely to the increase in FVIII/VWF (von Willebrand factor), as VWF/FVIII concentrates have no effect in these circumstances. Microparticles (MP) can support haemostasis by expression of phospholipids, tissue factor and VWF on their surface. We hypothesized that significant amounts of VWF are bound to MP after DDAVP administration and that consequently depletion of MP should influence VWF:Ag and VWF:RCo plasma levels. Platelet-poor plasma was either obtained well from healthy controls or before and after DDAVP administration from patients with von Willebrand's disease (type 1 or possible type 1) or patients with other bleeding disorders as controls. Concentrations of MP and VWF parameters were determined before and after MP depletion by different methods (magnetic bead selection, plasma microfiltration, ultracentrifugation). Platelet MP and VWF-bearing MP were significantly increased after DDAVP.
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CAS 118409-57-7 AG-18

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