Afuresertib HCl - CAS 1047645-82-8
Catalog number:
1047645-82-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H18Cl3FN4OS
Molecular Weight:
463.78
COA:
Inquire
Targets:
Akt
Description:
Afuresertib HCl is a potent pan-AKT inhibitor.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Related CAS:
1047644-62-1 (Free base)
Appearance:
Solid powder
Synonyms:
N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride; GSK2110183; GSK 2110183; GSK-2110183; GSK2110183B; GSK 2110183B; GSK2110183B; Afuresertib
MSDS:
Inquire
InChIKey:
YFQJOPFTGMHYNV-YDALLXLXSA-N
InChI:
1S/C18H17Cl2FN4OS.ClH/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10;/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26);1H/t12-;/m0./s1
Canonical SMILES:
O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)S1)N[C@@H](CC3=CC=CC(F)=C3)CN.[H]Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Akt Products


CAS 1047645-82-8 Afuresertib HCl

Afuresertib HCl
(CAS: 1047645-82-8)

Afuresertib HCl is a potent pan-AKT inhibitor.

CAS 1047634-63-8 GSK2110183

GSK2110183
(CAS: 1047634-63-8)

GSK2110183 is an orally bioavailable pan-Akt inhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively.

CAS 1431697-86-7 AT7867 dihydrochloride

AT7867 dihydrochloride
(CAS: 1431697-86-7)

AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50 of 20 nM and 85 nM, respectively. AT7867 shows ATP-competitive activity to Akt2 w...

CAS 1032349-93-1 MK-2206

MK-2206
(CAS: 1032349-93-1)

MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. It is also an orally bioavailable allosteric inhibitor of the serine/...

CAS 157716-52-4 Perifosine

Perifosine
(CAS: 157716-52-4)

Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane...

ARQ-092
(CAS: 1313881-70-7)

ARQ-092, also called as Miransertib, is an oral activie, potent and selective AKT inhibitor with IC50= 5.0 nM against AKT1, 4.5 nM against AKT2 and 16 nM agains...

CAS 1032350-13-2 MK-2206·2HCl

MK-2206·2HCl
(CAS: 1032350-13-2)

MK2206 is a Akt inhibitor, is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential anti...

CAS 842148-40-7 AKT Kinase Inhibitor

AKT Kinase Inhibitor
(CAS: 842148-40-7)

AKT Kinase Inhibitor is a Akt Kinase Inhibitor.

CAS 1047634-65-0 Uprosertib

Uprosertib
(CAS: 1047634-65-0)

Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potentia...

CAS 522-17-8 Deguelin

Deguelin
(CAS: 522-17-8)

Deguelin is a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers.

CAS 1004990-28-6 PF-AKT400

PF-AKT400
(CAS: 1004990-28-6)

PF-AKT400 is an APT competitor inhibitor of AKR kinase. This compound was first described as compound 42 in J. Med. Chem. 2010, 53, 4615–4622 by a group of Pfi...

XL-418
(CAS: 871343-09-8)

XL-418 is a 70 kDa ribosomal protein S6 kinase and Proto oncogene protein c-akt inhibitor. It can inhibit the activities of PKB and p70S6K, both acting downstre...

CAS 871361-88-5 SC66

SC66
(CAS: 871361-88-5)

SC66 is a novel and potent AKT inhibitor, which reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in...

CAS 552325-73-2 A-674563

A-674563
(CAS: 552325-73-2)

A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.

CAS 552325-16-3 A-443654

A-443654
(CAS: 552325-16-3)

A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines test...

CAS 1489263-16-2 Ipatasertib HCl

Ipatasertib HCl
(CAS: 1489263-16-2)

Ipatasertib, also known as GDC-0068, is a highly selective pan-Akt inhibitor targeting Akt1/2/3 (IC50= 5 nM/18 nM/8 nM in cell-free assays) with 620-fold select...

CAS 885499-61-6 CCT128930

CCT128930
(CAS: 885499-61-6)

CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine co...

CAS 1143532-39-1 AZD-5363

AZD-5363
(CAS: 1143532-39-1)

AZD5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AZD5363 binds to ...

CAS 1047644-62-1 Afuresertib

Afuresertib
(CAS: 1047644-62-1)

Afuresertib, also known as GSK2110183,  is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineo...

CAS 1047635-80-2 GSK2141795 hydrochloride

GSK2141795 hydrochloride
(CAS: 1047635-80-2)

GSK2141795 Hcl is a potent and selective pan-Akt inhibitor with IC50s of 180/328/38 nM for Akt1/Akt2/Akt3 respectively.

Chemical Structure

CAS 1047645-82-8 Afuresertib HCl

Quick Inquiry

Verification code

Featured Items