|Description||AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor and showed no inhibition or stimulation of >50% at 10μM in a standard selectivity panel of ca. 70 targets run at CEREP. AF38469 showed no activity against the NTR1 receptor. In addition|
|Synonyms||2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid CHEMBL3098745 AF38469 4n7e SCHEMBL15903106 BDBM50445054 ZINC95921158 HY-12802 KB-274741 n-(6-methylpyridin-2-yl)-5-trifluoromethyl-phthalamic acid|
|Solubility||Soluble to ≥ 43 mg/mL in DMSO|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -63℃ for long term (months to years).|
|Shelf Life||2 years|
|Boiling Point||392.3±42.0 °C | Condition: Press: 760 Torr|
BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM.
Hexafluronium bromide is .a cholinesterase inhibitor used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium durin...
Neuropeptide S (human)
Neuropeptide S (human), one of the "youngest" members among the biologically active peptides, is a potent endogenous neuropeptide S receptor agonist (EC50 = 9.4...
GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. It alters the pH dependence of ASIC1a and ASIC1b with no effect on the ...
NCT-503 is a non-competitive phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50= 2.5 µM), reducing the production of glucose-derived serine in cells and sup...
CDK2, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/...
Zoniporide dihydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor with selectivity over other NHE isoforms (Ki = 14, 2200 and 220000 n...
A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM), which attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Stu...