Adolezesin - CAS 110314-48-2
Catalog number:
110314-48-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H22N4O4
Molecular Weight:
502.52
COA:
Inquire
Targets:
Others
Description:
Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth. It has marginal efficacy in the treatment of metastatic breast cancer at the dosage and schedule used in clinic phase 1 and 2 trials. It was developed by Pharmacia and was terminated in clinic phase 2 trials.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
U73975;U-73975;N-(2-((7bR,8aS)-7-methyl-4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carbonyl)-1H-indol-5-yl)benzofuran-2-carboxamide
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Adozelesin has marginal efficacy in the treatment of metastatic breast cancer.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
766.2±60.0 °C | Condition: Press: 760 Torr
Density:
1.56±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
BYRVKDUQDLJUBX-JJCDCTGGSA-N
InChI:
InChI=1S/C30H22N4O4/c1-15-13-31-27-22(35)11-25-30(26(15)27)12-18(30)14-34(25)29(37)21-9-17-8-19(6-7-20(17)33-21)32-28(36)24-10-16-4-2-3-5-23(16)38-24/h2-11,13,18,31,33H,12,14H2,1H3,(H,32,36)/t18-,30+/m1/s1
Canonical SMILES:
CC1=CNC2=C1C34CC3CN(C4=CC2=O)C(=O)C5=CC6=C(N5)C=CC(=C6)NC(=O)C7=CC8=CC=CC=C8O7
Current Developer:
Adozelesin was developed by Pharmacia and was terminated in clinic phase 2 trials.
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CAS 110314-48-2 Adolezesin

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