Adiphenine hydrochloride - CAS 50-42-0
Catalog number: 50-42-0
Category: Inhibitor
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Molecular Formula:
C20H25NO2.HCl
Molecular Weight:
347.88
COA:
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Targets:
nAChR
Description:
Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
Purity:
>98%
MSDS:
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InChIKey:
LKPINBXAWIMZCG-UHFFFAOYSA-N
InChI:
InChI=1S/C20H25NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,19H,3-4,15-16H2,1-2H3;1H
Canonical SMILES:
CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl
1.Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives.
Attwood D. J Pharm Pharmacol. 1976 May;28(5):407-9.
Light scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphenine hydrochloride, piperidolate hydrochloride, benztropine mesylate, orphenadrine hydrochloride, chlorphenoxamine hydrochloride, lachesine hydrochloride, poldine methylsulphate, pipenzolate bromide, clidinium bromide, benzilonium bromide and ambutonium bromide. A micellar pattern of association was established for all compounds and critical micellar concentrations and aggregation numbers have been determined.
2.Kinetics of drug decomposition. Part 69: Effect of excipients on the thermal decomposition of the mixture of aminophenazone allobarbital and adiphenine hydrochloride in the solid.
Pawełczyk E, Marciniec B. Pharmazie. 1981 Aug;36(8):540-2.
By the method of accelerated testing at elevated temperature, the thermal decomposition rate of the mixture of aminophenazone (AP), allobarbital (AB) and adiphenine hydrochloride (AD) and its individual components in the presence of the excipients starch (potato), agar, talcum, kaolin and magnesium stearate is studied. The individual and joint effect of the excipients on the components of the mixture AP + AB + AD as well as on the mixture as a whole is determined and compared. The theoretically predicted stability of the components is discussed and compared with the results of "self-life" tests in the presence and absence of the excipients.
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CAS 50-42-0 Adiphenine hydrochloride

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