Adiphenine hydrochloride - CAS 50-42-0
Catalog number:
50-42-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H25NO2.HCl
Molecular Weight:
347.88
COA:
Inquire
Targets:
nAChR
Description:
Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives.
Attwood D. J Pharm Pharmacol. 1976 May;28(5):407-9.
Light scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphenine hydrochloride, piperidolate hydrochloride, benztropine mesylate, orphenadrine hydrochloride, chlorphenoxamine hydrochloride, lachesine hydrochloride, poldine methylsulphate, pipenzolate bromide, clidinium bromide, benzilonium bromide and ambutonium bromide. A micellar pattern of association was established for all compounds and critical micellar concentrations and aggregation numbers have been determined.
2.Kinetics of drug decomposition. Part 69: Effect of excipients on the thermal decomposition of the mixture of aminophenazone allobarbital and adiphenine hydrochloride in the solid.
Pawełczyk E, Marciniec B. Pharmazie. 1981 Aug;36(8):540-2.
By the method of accelerated testing at elevated temperature, the thermal decomposition rate of the mixture of aminophenazone (AP), allobarbital (AB) and adiphenine hydrochloride (AD) and its individual components in the presence of the excipients starch (potato), agar, talcum, kaolin and magnesium stearate is studied. The individual and joint effect of the excipients on the components of the mixture AP + AB + AD as well as on the mixture as a whole is determined and compared. The theoretically predicted stability of the components is discussed and compared with the results of "self-life" tests in the presence and absence of the excipients.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related nAChR Products


AZD 0328
(CAS: 220099-91-2)

AZD 0328 is a potent α7 NNR/5HT3 receptor agonist. AZD0328 led to a significant increase in cortical dopamine release in awake rodents and improved both conditi...

Facinicline
(CAS: 677306-35-3)

Facinicline is a partial agonist of the nicotinic alpha-7 (α7) receptor. It is used for the oral treatment of Alzheimer's. It was being co-developed by Roche an...

CAS 123464-89-1 PNU-282987

PNU-282987
(CAS: 123464-89-1)

Highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of ...

Nelonicline
(CAS: 1026134-63-3)

Nelonicline is an Alpha7 nicotinic acetylcholine receptor(nAChR) agonist and Nicotinic acetylcholine receptor agonist. It plays a key role in inflammatory proce...

CAS 96946-42-8 Cisatracurium besylate

Cisatracurium besylate
(CAS: 96946-42-8)

Cisatracurium besylate is a neuromuscular blocking agent that is used in liver transplant patient with safety. Cisatracurium besylate is also an enantiomer of A...

CAS 375815-87-5 Varenicline Tartrate

Varenicline Tartrate
(CAS: 375815-87-5)

Varenicline (trade name Chantix in the USA and Champix in Canada, Europe and other countries, marketed by Pfizer, usually in the form of varenicline tartrate), ...

CAS 220662-95-3 RJR-2403 oxalate

RJR-2403 oxalate
(CAS: 220662-95-3)

A neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Act...

CAS 501925-31-1 PNU-120596

PNU-120596
(CAS: 501925-31-1)

PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.

CAS 550999-75-2 EVP-6124

EVP-6124
(CAS: 550999-75-2)

EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). It shows selectivity for α7 nAChRs and did not activate or inhibi...

CAS 2468-21-5 Catharanthine

Catharanthine
(CAS: 2468-21-5)

Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.

CP-601932
(CAS: 357425-68-4)

CP-601932 is a CNS-penetrant, high affinity, and selective α(4) β(2) nicotinic acetylcholine receptors partial agonist.

CAS 550999-74-1 Encenicline, HCl salt

Encenicline, HCl salt
(CAS: 550999-74-1)

EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-ago...

CAS 198283-73-7 ABT-594

ABT-594
(CAS: 198283-73-7)

ABT-594, also called as Tebanicline, the (R)-enantiomer of A-98593, is a potent synthetic non-opioid nicotinic analgesic drug. ABT-594 is a novel nAChR ligan wh...

CP-601927
(CAS: 357425-02-6)

CP-601927 is a CNS-penetrant, high affinity, and selective nicotinic acetylcholine receptor (nAChR) agonist.

Bradanicline
(CAS: 639489-84-2)

Bradanicline acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studie...

A-366833
(CAS: 370882-41-0)

A-366833 is a an agonist at neural nicotinic acetylcholine receptors selective for the α4β2 subtype.

CAS 50-42-0 Adiphenine hydrochloride

Adiphenine hydrochloride
(CAS: 50-42-0)

Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.

CAS 153874-14-7 S16961

S16961
(CAS: 153874-14-7)

S16961 is a nicotinic receptor agonist with antihyperlipidaemic property which was developed for the treatment of Hyperlipidaemia in France (PO).

CP-810123
(CAS: 439608-12-5)

CP-810123 is a novel alpha 7 nAChR agonist with potential treatment for cognitive deficits associated with psychiatric or neurological conditions including schi...

CAS 15500-66-0 Pancuronium dibromide

Pancuronium dibromide
(CAS: 15500-66-0)

Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine。

Chemical Structure

CAS 50-42-0 Adiphenine hydrochloride

Quick Inquiry

Verification code

Featured Items