Aderbasib - CAS 791828-58-5
Catalog number:
791828-58-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation.
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Synonyms:
INCB7839; INCB007839
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Current Developer:
Incyte.
1.Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis.
Valdivia HO1,2, Reis-Cunha JL3, Rodrigues-Luiz GF4, Baptista RP5, Baldeviano GC6, Gerbasi RV7, Dobson DE8, Pratlong F9, Bastien P10, Lescano AG11,12, Beverley SM13, Bartholomeu DC14. BMC Genomics. 2015 Sep 18;16:715. doi: 10.1186/s12864-015-1928-z.
BACKGROUND: The Leishmania (Viannia) braziliensis complex is responsible for most cases of New World tegumentary leishmaniasis. This complex includes two closely related species but with different geographic distribution and disease phenotypes, L. (V.) peruviana and L. (V.) braziliensis. However, the genetic basis of these differences is not well understood and the status of L. (V.) peruviana as distinct species has been questioned by some. Here we sequenced the genomes of two L. (V.) peruviana isolates (LEM1537 and PAB-4377) using Illumina high throughput sequencing and performed comparative analyses against the L. (V.) braziliensis M2904 reference genome. Comparisons were focused on the detection of Single Nucleotide Polymorphisms (SNPs), insertions and deletions (INDELs), aneuploidy and gene copy number variations.
2.Globalization and eating disorder risk: peer influence, perceived social norms, and adolescent disordered eating in Fiji.
Gerbasi ME1, Richards LK, Thomas JJ, Agnew-Blais JC, Thompson-Brenner H, Gilman SE, Becker AE. Int J Eat Disord. 2014 Nov;47(7):727-37. doi: 10.1002/eat.22349. Epub 2014 Aug 19.
OBJECTIVE: The increasing global health burden imposed by eating disorders warrants close examination of social exposures associated with globalization that potentially elevate risk during the critical developmental period of adolescence in low- and middle-income countries (LMICs). The study aim was to investigate the association of peer influence and perceived social norms with adolescent eating pathology in Fiji, a LMIC undergoing rapid social change.
3.Differential association of chromatin proteins identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation.
Alajem A1, Biran A1, Harikumar A1, Sailaja BS1, Aaronson Y1, Livyatan I1, Nissim-Rafinia M1, Sommer AG2, Mostoslavsky G2, Gerbasi VR3, Golden DE4, Datta A5, Sze SK5, Meshorer E6. Cell Rep. 2015 Mar 31;10(12):2019-31. doi: 10.1016/j.celrep.2015.02.064. Epub 2015 Mar 26.
Embryonic stem cells (ESCs) possess a distinct chromatin conformation maintained by specialized chromatin proteins. To identify chromatin regulators in ESCs, we developed a simple biochemical assay named D-CAP (differential chromatin-associated proteins), using brief micrococcal nuclease digestion of chromatin, followed by liquid chromatography tandem mass spectrometry (LC-MS/MS). Using D-CAP, we identified several differentially chromatin-associated proteins between undifferentiated and differentiated ESCs, including the chromatin remodeling protein SMARCD1. SMARCD1 depletion in ESCs led to altered chromatin and enhanced endodermal differentiation. Gene expression and chromatin immunoprecipitation sequencing (ChIP-seq) analyses suggested that SMARCD1 is both an activator and a repressor and is enriched at developmental regulators and that its chromatin binding coincides with H3K27me3. SMARCD1 knockdown caused H3K27me3 redistribution and increased H3K4me3 around the transcription start site (TSS).
4.Assessment of recent graduates preparedness for entry into practice.
Cook KA1, Marienau MS2, Wildgust B3, Gerbasi F4, Watkins J5. AANA J. 2013 Oct;81(5):341-5.
To date no studies have been conducted to assess the preparedness of CRNA graduates for entry into practice by asking graduates and their respective employers to assess specific competencies. The purpose of this study was to assess recent graduates' preparation and performance. It was hypothesized recent graduates are prepared for entry into nurse anesthesia practice. This study was conducted between August 2011 and February 2012. An online survey tool was used to rate graduates' preparedness to perform 17 professional competencies. Surveys were distributed to 2349 CRNAs who graduated in 2009 and 2,663 employers who hired recent graduates. A power of 90% for employers and 85% for graduates was obtained (P = .05). Analysis of a sample size of 148 matched graduate-employer pairs provided 88% power. Overall, 98% of the graduates and 97% of the employers indicated graduates were prepared for practice. Of the 1,407 graduates assessed by employers, 1,343 (96%) would be hired again.
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