Adarotene - CAS 496868-77-0
Catalog number: 496868-77-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Apoptosis Inducer
Adarotene is an atypical retinoid and a promising anti-tumour agent with selective apoptotic activity on the leukaemic blast. The anti-tumour activity of the compound has been associated with its capacity to induce DNA double stranded breaks.
Publictions citing BOC Sciences Products
  • >> More
White to off-white solid
ST1926; ST 1926; ST-1926.
1.New retinoid derivatives as back-ups of Adarotene.
Giannini G1, Brunetti T, Battistuzzi G, Alloatti D, Quattrociocchi G, Cima MG, Merlini L, Dallavalle S, Cincinelli R, Nannei R, Vesci L, Bucci F, Foderà R, Guglielmi MB, Pisano C, Cabri W. Bioorg Med Chem. 2012 Apr 1;20(7):2405-15. doi: 10.1016/j.bmc.2012.01.042. Epub 2012 Feb 6.
Adarotene belongs to the so-called class of atypical retinoids. The presence of the phenolic hydroxyl group on Adarotene structure allows a rapid O-glucuronidation as a major mechanism of elimination of the drug, favoring a fast excretion of its glucuronide metabolite in the urines. A series of ether, carbamate and ester derivatives was synthesized. All of them were studied and evaluated for their stability at different pH. The cytotoxic activity in vitro on NCI-H460 non-small cell lung carcinoma and A2780 ovarian tumor cell lines was also tested. A potential back-up of Adarotene has been selected to be evaluated in tumor models.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Apoptosis Inducer Products

CAS 79183-19-0 Apoptosis Activator 2

Apoptosis Activator 2
(CAS: 79183-19-0)

CAS 697235-39-5 Episilvestrol

(CAS: 697235-39-5)

Episilvestrol is a derivative of Silvestrol, which is a member of flavagline family of natural products from the genus of Aglaia,

CAS 114899-77-3 Trabectedin

(CAS: 114899-77-3)

CAS 113558-15-9 Baohuoside I

Baohuoside I
(CAS: 113558-15-9)

A regulator of CXCR4 expression

CAS 35354-74-6 Honokiol

(CAS: 35354-74-6)

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation.

CAS 143360-00-3 SMIP004

(CAS: 143360-00-3)

SMIP004 a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, at low micromolar concentration it upregulated p27 in various prostat...

CAS 30636-90-9 (20S)-Protopanaxadiol

(CAS: 30636-90-9)

Protopanaxdiol, an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin extracted from the roots of Panax ginseng C. A. Mey. It is apoptosis...

CAS 78821-43-9 Epibrassinolide

(CAS: 78821-43-9)

Epibrassinolide is a biologically active compound of the brassinosteroids that can be isolated from various plants. It belongs steroid-derived plant growth regu...

(CAS: 4099-30-3)

Desacetylcinobufotalin is apoptosis inducer. shows the inhibition effect to HepG2 cells (IC50 =0.0279μmol/ml) .

CAS 496868-77-0 Adarotene

(CAS: 496868-77-0)

Adarotene is an atypical retinoid and a promising anti-tumour agent with selective apoptotic activity on the leukaemic blast. The anti-tumour activity of the co...

CAS 960365-65-5 Silvestrol aglycone

Silvestrol aglycone
(CAS: 960365-65-5)

Silvestrol aglycone, extracted from Aglaia foveolata, could induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of e...

(CAS: 697235-38-4)

A member of flavagline family of natural products from the genus of Aglaia, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway withou...

CAS 488832-69-5 Elesclomol

(CAS: 488832-69-5)

Elesclomol is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic...

CAS 553-21-9 Costunolide

(CAS: 553-21-9)

Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-...

CAS 147419-93-0 Ginsenoside Rg6

Ginsenoside Rg6
(CAS: 147419-93-0)

Ginsenoside Rg6, extracted from steamed notoginseng, exhibited significantly potent inhibitory effects on IL-12 p40 production in LPSstimulated BMDCs.

CAS 54522-52-0 Methylprotodioscin

(CAS: 54522-52-0)

A natural compound, source from roots of Dioscorea opposita Thunb, could block the volt dependent form calcium channel in cellular membrane, and up-regulate the...

CAS 18457-55-1 Perillyl Alcohol

Perillyl Alcohol
(CAS: 18457-55-1)

Perillyl Alcohol, or POH, a monoterpene derived from the mevalonate pathway in plants, induces apoptosis in colon tumor cells.

CAS 472-15-1 Betulinic acid

Betulinic acid
(CAS: 472-15-1)

betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induc...

CAS 97207-47-1 Methylisoindigotin

(CAS: 97207-47-1)

CAS 1968-05-4 Bis (3-indolyl)methane

Bis (3-indolyl)methane
(CAS: 1968-05-4)

3,3’-Diindolylmethane is a derivative of a phytochemical natural compound found in Brassicaceae(Indole-3-carbinol).It is works as an activator of Chk2 that caus...

Chemical Structure

CAS 496868-77-0 Adarotene

Quick Inquiry

Verification code

Featured Items