Actinonin - CAS 13434-13-4
Catalog number: 13434-13-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Canonical SMILES:
1.Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N.
Ganji RJ1, Reddi R, Gumpena R, Marapaka AK, Arya T, Sankoju P, Bhukya S, Addlagatta A. Protein Sci. 2015 May;24(5):823-31. doi: 10.1002/pro.2653. Epub 2015 Apr 8.
Actinonin is a pseudotripeptide that displays a high affinity towards metalloproteases including peptide deformylases (PDFs) and M1 family aminopeptidases. PDF and M1 family aminopeptidases belong to thermolysin-metzincin superfamily. One of the major differences in terms of substrate binding pockets between these families is presence (in M1 aminopeptidases) or absence (in PDFs) of an S1 substrate pocket. The binding mode of actinonin to PDFs has been established previously; however, it is not clear how the actinonin, without a P1 residue, would bind to the M1 aminopeptidases. Here we describe the crystal structure of Escherichia coli aminopeptidase N (ePepN), a model protein of the M1 family aminopeptidases in complex with actinonin. For comparison we have also determined the structure of ePepN in complex with a well-known tetrapeptide inhibitor, amastatin. From the comparison of the actinonin and amastatin ePepN complexes, it is clear that the P1 residue is not critical as long as strong metal chelating head groups, like hydroxamic acid or α-hydroxy ketone, are present.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 107753-78-6 Zafirlukast

(CAS: 107753-78-6)

Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of certain natural substances that cau...

CAS 1214-39-7 6-Benzylaminopurine

(CAS: 1214-39-7)

6-Benzylaminopurine, a purine-based first-generation synthetic cytokinin, could stimulate plant growth.

HLCL65 hydrochloride

HLCL65 hydrochloride is a first-in-class inhibitor of PRMT5. HLCL65 selectively inhibits Th1 cell proliferation (IC50 value 1.1 μM). In vivo, HLCL65 suppresses ...

CAS 68-88-2 Hydroxyzine

(CAS: 68-88-2)

Hydroxyzine is a histamine H1-receptor antagonist.

CAS 161611-99-0 DU125530

(CAS: 161611-99-0)

DU125530 is a selective 5-HT1A receptor antagonist (Ki = 0.7 nM). DU125530 has the potential to be used in the treatment of anxiety, depression and psychiatric ...

CAS 1895895-38-1 CHZ868

(CAS: 1895895-38-1)

CHZ868 is a potent and selective type II JAK2 inhibitor (IC50= 0.17 μM in EPOR JAK2 WT Ba/F3 cell). CHZ868 potently inhibited proliferation of cells expressing ...

CAS 923565-22-4 GSK 962040 hydrochloride

GSK 962040 hydrochloride
(CAS: 923565-22-4)

GSK 962040 hydrochloride is the hydrochloride form of GSK 962040, which is a selective motilin receptor agonist with pEC50 value of 7.9. It may be used as a tre...

(CAS: 945531-77-1)

Ezutromid, also known as BMN-195 and SMTC-1100, is an orally bioavailable and non-toxic small molecule that transcriptionally upregulates the utrophin gene (EC5...

Chemical Structure

CAS 13434-13-4 Actinonin

Quick Inquiry

Verification code

Featured Items