|Description||Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. It intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. It is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. It has potent antineoplastic activity. It is used in the treatment of cancer. It can induce histone eviction from chromatin upon intercalation. It has been listed.|
|Appearance||Yellow crystalline powder|
|Solubility||Soluble in DMSO (25mg/ml) or dimethyl formamide (25mg/ml).|
|Application||Aclarubicin has potent antineoplastic activity. It is used in the treatment of cancer. It can induce histone eviction from chromatin upon intercalation.|
|Quality Standard||In-house standard|
|Quantity||Kilograms to Tons|
|Boiling Point||897.7±65.0 °C | Condition: Press: 760 Torr|
|Melting Point||151-153 °C (decomp)|
|Density||1.42±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||Aclarubicin has been listed.|
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