|Description||Acitretin sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. It can be considered one of the treatments of choice for pustular and erythrodermic psoriasis. However, the efficacy of acitretin sodium as a monotherapy for plaque psoriasis is less, although it is often used in combination therapy with other systemic psoriasis therapies, especially ultraviolet B or psoralen plus ultraviolet A phototherapy, to increase efficacy. Such combination treatments may potentially minimise toxicity by using lower doses of each of the two agent.|
|Synonyms||Ro 10-1670 sodium; Soriatane sodium|
BMS 270394 is a nuclear retinoic acid receptor (RAR-γ) agonist.
SR 11237 is a pan retinoid X receptor (RXR) agonist with no RAR activity.
AGN 205728 is a potent and selective RARγ antagonist and has no inhibiton on RARα and RARβ.
LG 101506 is a selective RXR modulator.
NRX-204647 is a Retinoic acid receptor gamma-selective inverse agonist.
Adapalene is more active than indomethacin, betamethasone valerate, tretinoin, isotretinoin or etretinate in inhibiting lipoxygease activity, but it has little ...
Ch 55 is a highly potent synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. It has high affinity for RAR-α and RAR-β receptors, ...
Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors).