|Description||Acetyl Pepstatin is a high affinity HIV-1 protease inhibitor and aspartic protease inhibitor. It inhibits HIV-1 protease with Ki value of 20 nM at pH 4.7 and HIV-2 protease with Ki value of 5 nM at pH 4.7. It is used as an antiviral agent.|
|Synonyms||Ac-Pepstatin; [1S-[1R*,2R*,4[R*[R*(R*)]]]]-1-(2-Methylpropyl)-4-oxobutyl]-N-acetyl-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl]amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-L-valinamide; Pepsin Inhibitor S-PI-D (8CI); N-Acetyl-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6- methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-L-alaninamide; Pepsidin C; S-PI; (4S,7S,8S,10S,19S)-8-carbamoyl-11,19-dihydroxy-10,18-diisobutyl-4-isopropyl-7,15-dimethyl-2,5,13,16-tetraoxo-3,9,14,17-tetraazahenicosan-21-oic acid|
PD 099560, a benzopyran derivative, has been found to be a HIV-1 protease inhibitor that could be significant in HIV studies.
CC-3052, a thalidomide analogue, reduces persistent activation of the TNF-α system in HIV without markedly impairing neutrophil viability.
BMS-187071 has been found to be a HIV protease inhibitor that was once studied against HIV by Bristol-Myers Squibb.
CGP-75355 is an HIV Protease inhibitor (EC50= 0.7 nM).
DPC-681, sulfonamide derivatives, is an extremely potent and selective inhibitor of HIV protease. IC90s: wild-type HIV-1=4-40 nM
The hydrochloride salt form of MK-8718 which has been found to be a HIV protease inhibitor and could be studied in HIV research.
CI-1029 is a nonpeptidic inhibitor of HIV protease, potenat against mutant HIV protease and resistant HIV strains.
A potent inhibitor of HIV-l protease (IC50= 1 nM)