Acetildenafil (Hongdenafil) - CAS 831217-01-7
Catalog number: 831217-01-7
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Acetildenafil is a synthetic drug which acts as a phosphodiesterase inhibitor. It is an analog of sildenafil which has been detected in numerous different brands of supposedly "herbal" aphrodisiac products sold to boost libido and alleviate erectile dysfunction.
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5-[2-Ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-1,6-dihydro-1-methyl -3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one; Hongdenafil;
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1.Sildenafil citrate as a medical expulsive therapy for distal ureteric stones: A randomised double-blind placebo-controlled study.
Shokeir AA1, Tharwat MA1, Abolazm AE1, Harraz A1. Arab J Urol. 2016 Mar;14(1):1-6. doi: 10.1016/j.aju.2015.12.001. Epub 2016 Jan 21.
OBJECTIVE: To study the effect of sildenafil citrate on spontaneous passage of distal ureteric stones (DUS).
2.Bioequivalence of 2 Formulations of Sildenafil Oral Soluble Film 100 mg and Sildenafil Citrate (Viagra) 100 mg Oral Tablets in Healthy Male V
Dadey E1. Am J Ther. 2015 Jul 4. [Epub ahead of print]
Sildenafil citrate tablets (VIAGRA; Pfizer Inc) have been used since 1998 as an oral therapy for the treatment of erectile dysfunction. However, in some cases, patients may have difficulty in swallowing tablets, and the need to use water to aid in the oral administration of the tablets has the potential to interrupt the sexual encounter, reduce spontaneity, and therefore decrease the quality of the experience. Two oral soluble film (OSF) formulations of sildenafil were developed using MonoSol Rx's proprietary PharmFilm technology. Both films were formulated to dissolve rapidly on the tongue, thereby releasing the drug into the oral cavity, whereupon it is swallowed without the use of water. From a patient perspective, it is anticipated that the film formulations of sildenafil citrate will provide a more compliant and discreet dosage form. The purpose of this clinical study was to compare the bioequivalence of the 2 sildenafil OSF 100 mg formulations (MonoSol Rx, LLC) with the sildenafil citrate 100 mg tablets.
3.Rapid-Onset Sildenafil Sublingual Drug Delivery Systems: In Vitro Evaluation and In Vivo Pharmacokinetic Studies in Rabbits.
Sheu MT1, Hsieh CM2, Chen RN3, Chou PY1, Ho HO4. J Pharm Sci. 2016 Mar 14. pii: S0022-3549(16)00311-7. doi: 10.1016/j.xphs.2016.01.015. [Epub ahead of print]
The aim of the present study was to prepare sublingual delivery systems for sildenafil and evaluate its relative bioavailability after sublingual administration in rabbits to attain a rapid onset of action with good efficacy at lower doses. For sublingual application, sildenafil and its citrate were formulated in 2 different dosage forms: the first was a sublingual spray consisting of sildenafil in 2 microemulsion systems, oleic acid or propylene glycol (PG), and the second was sublingual tablets prepared with various granulated sublingual sprays adsorbed onto a silicate adsorbant (Florite® R), binders (Cyclocel® or EMDEX®), and disintegrants (Ac-Di-Sol® or Kollidon® CL). Results showed that sublingual absorption of sildenafil spray prepared with PG was fairly rapid. At a 0.5-mg dose, the mean onset of action was 1.3 ± 0.6 min and lasted for about 1.5 h according to the pharmacokinetic studies. In vivo studies also showed that for sublingual tablets formulated with sildenafil in PG adsorbed onto Florite® R at a 1:1 weight ratio then mixed with Cycloel® and Ac-Di-Sol®, the onset action was fast at 1.
4.Effects of Sildenafil Citrate and Heparin Treatments on Placental Cell Morphology in a Murine Model of Pregnancy Loss.
Luna RL1, Vasconcelos AG, Santana Nunes AK, de Oliveira WH, Barbosa KP, Peixoto CA. Cells Tissues Organs. 2016;201(3):193-202. doi: 10.1159/000444123. Epub 2016 Mar 16.
Lipopolysaccharide (LPS) injections during pregnancy are well established as models for pregnancy complications, including fetal growth restriction (FGR), thrombophilia, preterm labor and abortion. Indeed, inflammation, as induced by LPS injection has been described as a pivotal factor in cases of miscarriage related to placental tissue damage. The phosphodiesterase-5 inhibitor sildenafil (Viagra®) is currently used to treat FGR cases in women, while low-molecular weight heparin (Fragmin®) is a standard treatment for recurrent miscarriage (RM). However, the pathways and cellular dynamics involved in RM are not completely understood. The aim of this study was to evaluate the protective effect of sildenafil and dalteparin in a mouse model of LPS-induced abortion. Histopathology, ultrastructural analysis and immunofluorescence for P-selectin were studied in two different placental cell types: trophoblast cells and labyrinth endothelial cells.
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CAS 831217-01-7 Acetildenafil (Hongdenafil)

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