aceprometazine - CAS 13461-01-3
Catalog number: 13461-01-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H22N2OS
Molecular Weight:
326.46
COA:
Inquire
Targets:
Histamine Receptor
Description:
Aceprometazine is a Histamine H1 receptor antagonist as an approved drug. It can be used in combination with meprobamate for the treatment of sleep disorders such as Insomnia.
Purity:
95%
Appearance:
Powder
Synonyms:
aceprometazine;1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]ethanone;Acepromethazine
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Insomnia
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
490.1ºC at 760mmHg
Density:
1.154g/cm3
InChIKey:
XLOQNFNTQIRSOX-UHFFFAOYSA-N
InChI:
InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3
Canonical SMILES:
CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(=O)C)N(C)C
1.Abusive prescription of psychostimulants: a study of two cases.
Pélissier-Alicot AL;Piercecchi-Marti MD;Bartoli C;Kuhlmann E;Coiffait PE;Sanvoisin A;Giocanti D;Léonetti G J Forensic Sci. 2006 Mar;51(2):407-10.
Because psychostimulants have serious possible side effects and particular potential for abuse, their therapeutic indications are today exclusively limited to disorders such as obesity, narcolepsy, or attention deficit/hyperactivity disorder. We report two cases of abusive prescription of these drugs. The first concerns a woman who was treated for a 3 kg weight gain with fenproporex for 5 years and presented a withdrawal syndrome when this drug was no longer marketed in France. In the second case, a woman who complained of atypical sleep problems was prescribed modafinil, methylphenidate, clobazam, lormetazepam, meprobamate, and aceprometazine, and was found dead in her home a few weeks later in unexplained circumstances. For these two patients, neither the indications, nor the contraindications, nor the prescribing rules for these restricted drugs had been complied with. This case report highlights the extreme danger of these substances and stresses the importance of adhering to the rules of prescription.
2.Meprobamate-induced fixed drug eruption.
Zaïem A;Kaabi W;Badri T;Lakhoua G;Sahnoun R;Kastalli S;Daghfous R;Lakhal M;El Aidli S Curr Drug Saf. 2014;9(2):161-2.
Meprobamate is usually a safe drug prescribed for anxiety disorders. Fixed drug eruption (FDE) is an exceptional cutaneous adverse effect of this drug. We report a case of FDE induced by meprobamate with positive patch test. A 22-year-old woman was prescribed for depression meprobamate, aceprometazine, valpromide and lorazepam. On the second day of treatment, the patient presented red erythematous and pruriginous plaques in the limbs and the face. After stopping the previous treatment, the patient's lesions resolved completely within 3 weeks with residual pigmentation. One month later, patch tests were performed and were positive to meprobamate. Exceptional cases of FDE were reported in literature with meprobamate. None has reported the use of patch test to confirm the diagnosis.
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CAS 13461-01-3 aceprometazine

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