Aceglutamide - CAS 2490-97-3
Catalog number: 2490-97-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C7H12N2O4
Molecular Weight:
188.18
COA:
Inquire
Targets:
Others
Description:
Aceglutamide, also called as Glumal or acetylglutamine, is able to improve memory and concentration as psychostimulant and nootropic.
Purity:
95%
Appearance:
White Crystal
Synonyms:
(2S)-2-acetamido-5-amino-5-oxopentanoic acid aceglutamide aceglutamide, aluminum (3:1) salt N-acetyl-L-glutamine N-acetylglutamine
Solubility:
Soluble to 13mg/mL in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -122℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Data not available, please inquire.
Boiling Point:
604.9ºC at 760 mmHg
Melting Point:
206-208ºC
Density:
1.29 g/cm3
InChIKey:
KSMRODHGGIIXDV-YFKPBYRVSA-N
InChI:
1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1
Canonical SMILES:
CC(=O)NC(CCC(=O)N)C(=O)O
1.Identification of amino acid and glutathione N-conjugates of toosendanin: bioactivation of the furan ring mediated by CYP3A4.
Yu J1, Deng P, Zhong D, Chen X. Chem Res Toxicol. 2014 Sep 15;27(9):1598-609. doi: 10.1021/tx5002145. Epub 2014 Aug 19.
Toosendanin (TSN) is a hepatotoxic triterpenoid extracted from Melia toosendan Sieb et Zucc. Considering that TSN contains the structural alert of the furan ring, it is believed that bioactivation of TSN may be responsible for its toxicity. Herein, the bioactivation potential and metabolism profiles of TSN were investigated. After an oral administration of 10 mg/kg TSN to rats, esterolysis and conjugation with amino acids were identified as the main metabolic pathways. The same types of conjugates were detected in liver microsomes in an NADPH-dependent manner. According to the remaining amount of the parent drug, the reactivity of trapping reagents with TSN reactive metabolites was sorted in a decreasing order of N(α)-(tert-butoxycarbonyl)-l-lysine (Boc-Lys) > alanine, lysine, taurine, phenylalanine, serine, glutamic acid, glycine, and glutathione (GSH) > cysteine. No conjugates were observed in NADPH and N-acetyl cysteine (NAC)-supplemented human liver microsomal incubations.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 1707147-26-9 THK5351

THK5351
(CAS: 1707147-26-9)

THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain. THK5351 bound to AD hippocampal homogenates with high a...

CAS 5451-09-2 5-Aminolevulinic acid hydrochloride

5-Aminolevulinic acid hydrochloride
(CAS: 5451-09-2)

5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. 5-Aminolevulinic acid is used as a p...

SHP099 dihydrochloride

SHP099 is a potent and small-molecule inhibitor that has selectivity for SHP2 over SHP1 (IC50 = 0.071 μM), which is orally bioavailable. In xenograft models, SH...

CAS 69698-54-0 VIP(6-28)(human, rat, porcine, bovine)

VIP(6-28)(human, rat, porcine, bovine)
(CAS: 69698-54-0)

An effective antagonist of the actions of exogenous vasoactive intestinal peptide (VIP) on cAMP.

CAS 607-80-7 Sesamin

Sesamin
(CAS: 607-80-7)

Sesamin is a lignan isolated from the bark of Fagara plants and from sesame oil. It acts as a non-competitive inhibitor of Δ5-desaturase, and reduces cholestero...

CAS 38048-32-7 NBMPR

NBMPR
(CAS: 38048-32-7)

NBMPR is an equilibrative nucleoside transporter (ENT) 1 inhibitor.

CAS 882288-28-0 AI-3

AI-3
(CAS: 882288-28-0)

AI-3 is an antioxidant response element activator and could probably be useful in studies of oxidative stress related diseases.

CAS 36330-85-5 Fenbufen

Fenbufen
(CAS: 36330-85-5)

Fenbufen is a non-steroidal anti-inflammatory synthetic active reagent.

Chemical Structure

CAS 2490-97-3 Aceglutamide

Quick Inquiry

Verification code

Featured Items