Acebutolol hydrochloride - CAS 34381-68-5
Catalog number:
34381-68-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H28N2O4.HCl  
Molecular Weight:
372.89
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Acebutolol hydrochloride
MSDS:
Inquire
1.First Case Report of Smith-Magenis Syndrome (SMS) Among the Arab Community in Nazareth: View and Overview.
Nijim Y1, Adawi A, Bisharat B, Bowirrat A. Medicine (Baltimore). 2016 Jan;95(3):e2362. doi: 10.1097/MD.0000000000002362.
Smith-Magenis syndrome (SMS0) is a complex and rare genetic multisystem disorder characterized by a variable pattern of cognitive deficits accompanied by a1 distinctive behavioral phenotype. SMS is characterized by subtle facial dysmorphology, short stature, sleep disturbances, and neurobehavioral abnormalities. Little is known about the manifestation of his unique case among Arab population and its strategic treatment.This study comes to present a case of SMS in an Arab newborn male who was born in spontaneous delivery on June 29, 2015, with tachypnea, tracheomalacia, and mild hypotonia. The newborn was admitted on the Neonatal Intensive Care Unit (NICU), and various laboratory examinations and clinical examinations were performed.Throughout his hospitalization, feeding difficulties appeared and thus a peripheral venous catheter was inserted in the left leg.After 22 days of follow-up and hospitalizations, the patient status improved and he was discharged with recommendations to be in follow up in pediatric outpatient clinic.
2.Aqueous chlorination of acebutolol: kinetics, transformation by-products, and mechanism.
Khalit WN1, Tay KS2. Environ Sci Pollut Res Int. 2016 Feb;23(3):2521-9. doi: 10.1007/s11356-015-5470-y. Epub 2015 Oct 1.
This study investigated the reaction kinetics and the transformation by-products of acebutolol during aqueous chlorination. Acebutolol is one of the commonly used β-blockers for the treatment of cardiovascular diseases. It has been frequently detected in the aquatic environment. In the kinetics study, the second-order rate constant for the reaction between acebutolol and chlorine (k app) was determined at 25 ± 0.1 °C. The degradation of acebutolol by free available chlorine was highly pH dependence. When the pH increased from 6 to 8, it was found that the k app for the reaction between acebutolol and free available chlorine was increased from 1.68 to 11.2 M(-1) min(-1). By comparing with the reported k app values, the reactivity of acebutolol toward free available chlorine was found to be higher than atenolol and metoprolol but lower than nadolol and propranolol. Characterization of the transformation by-products formed during the chlorination of acebutolol was carried out using liquid chromatography-quadrupole time-of-flight high-resolution mass spectrometry.
3.Development of SPME-LC-MS method for screening of eight beta-blockers and bronchodilators in plasma and urine samples.
Goryński K1, Kiedrowicz A2, Bojko B3. J Pharm Biomed Anal. 2016 Mar 4. pii: S0731-7085(16)30119-4. doi: 10.1016/j.jpba.2016.03.001. [Epub ahead of print]
The current work describes the development and validation of a simple, efficient, and fast method using solid phase microextraction coupled to liquid chromatography-tandem mass spectrometry (SPME-LC-MS/MS) for the concomitant measurement of eight beta-blockers and bronchodilators in plasma and urine. The presented assay enables quantitative determination of acebutolol, atenolol, fenoterol, nadolol, pindolol, procaterol, sotalol, and timolol. In this work, samples were prepared on a high-throughput platform using the 96-well plate format of the thin film solid phase microextraction (TFME) system, and a biocompatible extraction phase made of hydrophilic-lipophilic balance particles. Analytes were separated on a pentafluorophenyl column (100mm×2.1mm, 3μm) by gradient elution using an UPLC Nexera coupled with an LCMS-8060 mass spectrometer. The mobile phase consisted of water-acetonitrile (0.1% formic acid) at a flow rate of 0.4mLmin-1. The linearity of the method was checked within therapeutic blood-plasma concentrations, and shown to adequately reflect typically expected concentrations of future study samples.
4.Upregulation of P-glycoprotein expression by ophthalmic drugs in different corneal in-vitro models.
Verstraelen J1, Reichl S. J Pharm Pharmacol. 2015 May;67(5):605-15. doi: 10.1111/jphp.12357. Epub 2015 Jan 23.
OBJECTIVES: The purpose of this study was to analyse P-glycoprotein (P-gp) expression in different human in-vitro cornea models (HCE-T epithelial model and Hemicornea construct) after stimulation with P-gp substrates (rhodamine 123, levofloxacin and acebutolol).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 86347-15-1 Medetomidine HCl

Medetomidine HCl
(CAS: 86347-15-1)

Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.

CAS 23256-50-0 Guanabenz Acetate

Guanabenz Acetate
(CAS: 23256-50-0)

Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respe...

CAS 118457-14-0 Nebivolol

Nebivolol
(CAS: 118457-14-0)

Nebivolol, a highly selective β1-adrenergic receptor inhibitor, has vasodilatory effect so that could be effective against hypertension. It was just withdrawed ...

CAS 81403-68-1 Alfuzosin HCl

Alfuzosin HCl
(CAS: 81403-68-1)

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

CAS 104054-27-5 Atipamezole

Atipamezole
(CAS: 104054-27-5)

Atipamezole, a 4-substituted imidazole derivative, is an alpha2-adrenoceptor blocker which could be used for animals to recover from the anesthesia by lowering ...

CAS 77883-43-3 Doxazosin Mesylate

Doxazosin Mesylate
(CAS: 77883-43-3)

Doxazosin mesylate is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia.

CAS 108929-47-1 CGP-12388

CGP-12388
(CAS: 108929-47-1)

CGP-12388 is a beta-adrenoceptor antagonist-derived radioligands. It is used for cardiac PET imaging due to its high hydrophilicity and affinity to beta-adrenoc...

CAS 51384-51-1 Metoprolol

Metoprolol
(CAS: 51384-51-1)

Metoprolol is a a selective β1 receptor blocker for the treatment of a variety of cardiovascular disorder.

CAS 21498-08-8 Lofexidine hydrochloride

Lofexidine hydrochloride
(CAS: 21498-08-8)

Lofexidine hydrochloride is the hydrochloride salt form of Lofexidine. Lofexidine, an analogue of clonidine, is an α2A-adrenergic receptor agonist for the treat...

CAS 964-52-3 Moxisylyte hydrochloride

Moxisylyte hydrochloride
(CAS: 964-52-3)

Moxisylyte hydrochloride is alpha 1-adrenoceptor antagonist. It can vasodilates cerebral vessels without reducing blood pressure. It is used as peripheral vasod...

CAS 1491-59-4 Oxymetazoline

Oxymetazoline
(CAS: 1491-59-4)

Oxymetazoline, an imidazol derivative, has been found to be an adrenergic receptor agonist that could be an effective topical decongestant.

CAS 106133-20-4 Tamsulosin

Tamsulosin
(CAS: 106133-20-4)

Tamsulosin could block on the sympathetic α1 receptor, especially selectively bind to the α1A receptor and has been found to be effective in the treatment of be...

CAS 5874-97-5 Metaproterenol hemisulfate salt

Metaproterenol hemisulfate salt
(CAS: 5874-97-5)

Metaproterenol hemisulfate salt is the hemisulfate salt form of Metaproterenol, which is a moderately selective beta-adrenergic agonist. It is used in the treat...

Dobutamine HCl
(CAS: 49745-95-1)

Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors o...

TAK-259 HCl
(CAS: 1192347-42-4)

This active molecular is a selective α1D Adrenergic Receptor antagonist. ( Ki value of 1.1 nM, 200 fold selective over α1A and 800 fold selective over α1B). TAK...

CAS 18559-94-9 Salbutamol

Salbutamol
(CAS: 18559-94-9)

Salbutamol is a short-acting agonist that specifically targets β2-adrenergic receptor to alleviate bronchospasm in conditions such as asthma and chronic obstruc...

CAS 119942-70-0 MK-912 hydrochloride

MK-912 hydrochloride
(CAS: 119942-70-0)

MK-912 is a potent new selective alpha 2-adrenergic receptor antagonist that is originated by Merck & Co for the treatment of Major depressive disorder. In Dec ...

CAS 54765-26-3 Lerimazoline

Lerimazoline
(CAS: 54765-26-3)

Lerimazoline is an α-adrenergic receptor agonist. It inhibits secretion of nasal mucus. It causes hypertension. It is common used in the form of hydrochloride.

CAS 56392-17-7 Metoprolol Tartrate

Metoprolol Tartrate
(CAS: 56392-17-7)

Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

(RS)-Butyryltimolol

(RS)-Butyryltimolol is the racemate of Butyryltimolol which is the butyryl ester of Timolol. Timolol, in the non-selective β blocker family of medication, has b...

Chemical Structure

CAS 34381-68-5 Acebutolol hydrochloride

Quick Inquiry

Verification code

Featured Items