| Molecular Formula: | |
|---|---|
| Molecular Formula | C21H16FN7O |
| Molecular Weight: | |
| Molecular Weight | 401.405 |
| COA: | |
| COA | Inquire |
| Targets: | |
| Targets | PI3K |
| Description: | |
| Description | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. |
| Appearance: | |
|---|---|
| Appearance | Solid powder |
| Synonyms: | |
| Synonyms | GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. |
| MSDS: | |
| MSDS | Inquire |
| InChIKey: | |
|---|---|
| InChIKey | DOCINCLJNAXZQF-LBPRGKRZSA-N |
| InChI: | |
| InChI | InChI=1S/C21H16FN7O/c1-12(27-19-17-18(24-10-23-17)25-11-26-19)20-28-16-8-7-13(22)9-15(16)21(30)29(20)14-5-3-2-4-6-14/h2-12H,1H3,(H2,23,24,25,26,27)/t12-/m0/s1 |
| Canonical SMILES: | |
| Canonical SMILES | CC(C1=NC2=C(C=C(C=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5 |
| Current Developer: | |
| Current Developer | Gilead Sciences |
LY 294002 hydrochloride
(CAS: 934389-88-5)
LY 294002 hydrochloride is a PI 3-kinase inhibitor with IC50 values of 0.31μM for PI 3-Kβ, 0.73μM for PI 3-Kα, 1.06μM for PI 3-Kδ and 6.60μM for PI 3-Kγ. It can...
BKM120
(CAS: 1202777-78-3)
BKM120, also called as buparlisib or NVP-BKM120, activity in a range of preclinical cancermodels, specifically inhbits class I PI3K isoforms, which blocks p110α...
SF2523
(CAS: 1174428-47-7)
SF2523 is a dual inhibitor of phosphatidylinositol 3-kinase and bromodomain-containing protein 4 with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for ...
GDC0941
(CAS: 957054-30-7)
GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K that inhibits p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM.
1,3-Dicaffeoylquinic acid
(CAS: 19870-46-3)
1,3-Dicaffeoylquinic acid, a caffeoylquinic acid derivative found in artichoke, acts as an anti-hyperlipidemic agent and activates PI3K/Akt.
ON 146040
(CAS: 1404231-34-0)
ON 146040 was highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. In biochemical testing, ON 146040 inhibited PI3K α...
AM-0687
(CAS: 1259522-94-5)
This active molecular is a selective PI3Kδ inhibitor. PI3Kδ is hyperactivated in B-cell malignancies and plays a vital role in the B-cell receptor pathway. AM-0...
740 Y-P
(CAS: 1236188-16-1)
740 Y-P is a cell-permeable phosphopeptide activator of PI3K. It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain ...
Chemical Structure
