Ac-LETD-AFC - CAS 210345-02-1
Molecular Formula:
C31H38F3N5O12
Molecular Weight:
729.7
COA:
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Application\Fluorophore:
Fluorescent Enzyme Substrates
Description:
Ac-LETD-AFC is a fluorogenic substrate for caspase-8. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Sequence:
Ac-Leu-Glu-Thr-Asp-Unk
Purity:
≥95%
Appearance:
Solid Powder
Synonyms:
N-Acetyl-Leu-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin; N-acetyl-L-leucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine
Storage:
Store at -20°C
MSDS:
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Excitation:
400 nm
Emission:
505 nm
InChIKey:
KTZOWCXXAYFIFT-XSSXFGQWSA-N
InChI:
InChI=1S/C31H38F3N5O12/c1-13(2)9-20(35-15(4)41)29(49)37-19(7-8-23(42)43)27(47)39-26(14(3)40)30(50)38-21(12-24(44)45)28(48)36-16-5-6-17-18(31(32,33)34)11-25(46)51-22(17)10-16/h5-6,10-11,13-14,19-21,26,40H,7-9,12H2,1-4H3,(H,35,41)(H,36,48)(H,37,49)(H,38,50)(H,39,47)(H,42,43)(H,44,45)/t14-,19+,20+,21+,26+/m1/s1
Canonical SMILES:
CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C
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Chemical Structure

CAS 210345-02-1 Ac-LETD-AFC

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