AC 186 - CAS 1421854-16-1
Catalog number:
1421854-16-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H17F3O
Molecular Weight:
306.32
COA:
Inquire
Targets:
Amyloid-β
Description:
AC 186, also called GTPL8897, a diphenyl substituted cyclohexane derivatives, decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
Decreases Aβ levels in combination with ACP-105
Appearance:
White solid
Synonyms:
4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol; GTPL8897; SCHEMBL14672438; AC 186; AKOS025147323; 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol; AC 186|4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
MSDS:
Inquire
Application:
Anti-Alzheimer agents; Amyloid-β inhibitor
InChIKey:
HSMUKSLNDJOZQG-UHFFFAOYSA-N
InChI:
1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2
Canonical SMILES:
C1CC(CCC1(C2=CC=C(C=C2)O)C3=CC=CC=C3F)(F)F
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Amyloid-β Products


LPYFD-NH2
(CAS: 700361-48-4)

LPYFD-NH2, is a neuroprotective peptide that binds to Amyloid-β. In vitro and in vivo it protects neurons against toxic effects of Aβ (1-42), which can be used ...

CAS 867021-83-8 Colivelin

Colivelin
(CAS: 867021-83-8)

Colivelin, as a neuroprotective peptide and activator of STAT3 it is able to suppresses neuronal death. It is also able to protect neurons against the neurotoxi...

CAS 97657-92-6 Dimebon dihydrochloride

Dimebon dihydrochloride
(CAS: 97657-92-6)

Dimebon dihydrochloride, also called Latrepirdine HCl, an orally-available non-selective antihistamine drug, it was explored the potention to treat Alzheimer's ...

CAS 145915-58-8 CGP 52411

CGP 52411
(CAS: 145915-58-8)

CGP 52411, also called DAPH, inhibits and reverses the formation of Aβ42 fibers (β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 µM) in neurons assoc...

CAS 26130-02-9 Frentizole

Frentizole
(CAS: 26130-02-9)

Frentizole, a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus, displayed a slightly impr...

CAS 1146963-51-0 J 147

J 147
(CAS: 1146963-51-0)

J 147, under the IUPAC name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide, a phenyl hydrazide compound that has been...

Amyloid β-peptide (42-1) (human)
(CAS: 317366-82-8)

Amyloid β-peptide (42-1) (human), is the predominant form of amyloid β-peptide found in the brains of patients with Alzheimer's disease.

CAS 156177-65-0 CEP 1347

CEP 1347
(CAS: 156177-65-0)

CEP 1347, also named KT 7515 or CHEMBL290352, is an ethylthiomethyl derivative, is a potent, selective inhibitor of the cJun-amino terminal kinase pathway curre...

CAS 956128-01-1 SEN 1269

SEN 1269
(CAS: 956128-01-1)

SEN 1269, under the IUPAC name 3-[[5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl]amino]phenol, is a derivative of pyrimidine that inhibits Amyloid-β (Aβ) aggregati...

CAS 131602-53-4 Amyloid beta-peptide(25-35)

Amyloid beta-peptide(25-35)
(CAS: 131602-53-4)

Amyloid beta-peptide(25-35), the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, is functionally required for the neurotrophic and neurotoxic effects a...

AC 186
(CAS: 1421854-16-1)

AC 186, also called GTPL8897, a diphenyl substituted cyclohexane derivatives, decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's dise...

CAS 173550-33-9 Compound W

Compound W
(CAS: 173550-33-9)

Compound W, also called 3,5-bis(4-Nitrophenoxy)benzoic acid, a 3,3'-diiodothyronine sulfate cross-reactive substance, is an inhibitor of γ-secretase which cause...

CAS 208255-80-5 DAPT

DAPT
(CAS: 208255-80-5)

DAPT, also called γ-Secretase Inhibitor IX, is a potent and selective inhibitor of γ-secretase which leads to a reduction in Aβ40 and Aβ42 levels in human prima...

CAS 677746-25-7 K 01-162

K 01-162
(CAS: 677746-25-7)

K 01-162 binds and destabilizes AβO (β-amyloid( EC50= 0.080 mM; IC50= 80 nM), can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble...

CAS 568-72-9 Tanshinone IIA

Tanshinone IIA
(CAS: 568-72-9)

Tanshinone IIA, under the IUPAC name 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione, one of the original anthracyclines isolated from Sa...

Methoxy-X04
(CAS: 863918-78-9)

Methoxy-X04, also called CHEMBL2181036, as a Fluorescent Amyloid-β (Aβ) probe, can be easily synthesized with carbon-11 (11C), it can detect and quantify plaque...

CRANAD 2
(CAS: 1193447-34-5)

CRANAD 2, a difluoroboron-derivatized curcumins, is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. It penetrates the blood-brain barrier and shows...

CAS 313967-18-9 FLI-06

FLI-06
(CAS: 313967-18-9)

FLI-06 , a Notch inhibitor that disrupts Notch trafficking and processing, disrupts the Golgi by mechanisms different from BFA or GCA. It Reduces amyloid β secr...

CAS 290315-45-6 BMS 299897

BMS 299897
(CAS: 290315-45-6)

BMS 299897, under the IUPAC name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid, synthesized by the radiosynth...

CAS 35825-57-1 Cryptotanshinone

Cryptotanshinone
(CAS: 35825-57-1)

Cryptotanshinone, a natural cell-permeable diterpene quinone isolated from Salvia miltiorrhiza, it inhibits acetylcholinesterase (IC50 = 4.09 μM) and reduces Aβ...

Quick Inquiry

Verification code

Featured Items