|Description||ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015.|
|Solubility||Soluble in DMSO, not in water|
|Application||ABTL-0812 has potential antineoplastic activity. It is used for the treatment of solid tumors|
|Quality Standard||In-house standard|
|Boiling Point||409.7±30.0 °C | Condition: Press: 760 Torr|
|Density||0.970±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||ABTL-0812 was developed by Ability Pharmaceuticals and is in phase I/II clinical trials. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015.|
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