ABT116 - CAS 1008529-42-7
Catalog number: 1008529-42-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C23H27F3N4O
Molecular Weight:
432.49
COA:
Inquire
Targets:
Others
Description:
ABT116 is an antagonist of transient receptor potential vanilloid type 1.
Purity:
>98 %
Appearance:
Solid powder
Synonyms:
ABT-116;1-[[2-(3,3-dimethylbutyl)-4-(trifluoromethyl)phenyl]methyl]-3-(1-methylindazol-4-yl)urea
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
511.7±50.0 °C | Condition: Press: 760 Torr
Density:
1.21±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
SMJCAASNPAKOIB-UHFFFAOYSA-N
InChI:
InChI=1S/C23H27F3N4O/c1-22(2,3)11-10-15-12-17(23(24,25)26)9-8-16(15)13-27-21(31)29-19-6-5-7-20-18(19)14-28-30(20)4/h5-9,12,14H,10-11,13H2,1-4H3,(H2,27,29,31)
Canonical SMILES:
CC(C)(C)CCC1=C(C=CC(=C1)C(F)(F)F)CNC(=O)NC2=CC=CC3=C2C=NN3C
1.Efficacy of ABT-116, an antagonist of transient receptor potential vanilloid type 1, in providing analgesia for dogs with chemically induced synovitis.
Cathcart CJ;Johnston SA;Reynolds LR;Al-Nadaf S;Budsberg SC Am J Vet Res. 2012 Jan;73(1):19-26. doi: 10.2460/ajvr.73.1.19.
OBJECTIVE: ;To investigate the ability of ABT-116 (a proprietary antagonist of transient receptor potential vanilloid type 1) administered at 2 doses to attenuate lameness in dogs with experimentally induced urate synovitis.;ANIMALS: ;8 purpose-bred mixed-breed dogs.;PROCEDURES: ;In a 4-way crossover study, dogs orally received each of low-dose ABT-116 treatment (LDA; 10 mg/kg), high-dose ABT-116 treatment (HDA; 30 mg/kg), firocoxib (5 mg/kg), and no treatment (nontreatment) once a day for 2 days, in a randomly assigned order. Synovitis was induced on the second day of each treatment period by intra-articular injection of either stifle joint with sodium urate, alternating between joints for each treatment period, beginning with the left stifle joint. Ground reaction forces, clinical lameness scores, and rectal temperature were assessed before the injection (baseline) and at various points afterward.;RESULTS: ;Lameness scores at the 2-, 6-, and 12-hour assessment points were higher than baseline scores for HDA and nontreatment, whereas scores at the 2- and 6-hour points were higher than baseline scores for LDA. For firocoxib, there was no difference from baseline scores in lameness scores at any point.
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