|Description||A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-fold higher in vitro affinity for dopamine D₃ versus D₂ receptors.|
|Synonyms||(E)-but-2-enedioic acid;2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one; UNII-DMH23OL273; 220519-07-3 (anhydrous); 220519-06-2 (anhydrous free base); ABT-925 anhydrous|
ABT-724 is a dopamine D4 agonist originated by Abbott Laboratories with EC50 value of 12.4 nM. In Dec 2007, Phase-II for Erectile dysfunction was discontinued i...
Pramipexole impurity D
The dihydrochloride salt form of dexpramipexole, also known as R-(+)-Pramipexole, is one of the impurities of pramipexole. It coule be used as a negative contro...
PD-120697 is a novel dopamine antagonist with central dopamine agonist properties. It was identified as orally active dopamine (DA) agonists with pronounced cen...
Remoxipride is a selective dopamine D2 receptor antagonist. It shows selectivity over D3 and D4 receptors with Ki values are ~ 300nM for D2 receptor, ~ 1600nM f...
Ecopipam, a synthetic benzazepine derivative drug, acts as a selective dopamine D1/D5 receptor antagonist with little affinity for either dopamine D2-like or 5-...
Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties.
Zuclopenthixol is an antagonist at D1 and D2 dopamine receptors. It also has high affinity for alpha1-adrenergic and 5-HT2 receptors, but it has weaker histamin...
Etybenzatropine is an anticholinergic/antihistamine. It is used as an antiparkinsonian agent. It may act as a dopamine reuptake inhibitor.
Veralipride is a D2 receptor antagonist in the hypothalamic system and has a half-life of approximately 12 hours. Veralipride is highly active on the neurotrans...
ABT670 is a drug which acts as a potent, superior orally bioavailable dopamine agonist selective for the D4 subtype. It was used as a possible treatment for ere...
Fluphenazine, sold under the brand names Prolixin
Clozapine is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.
Sumanirole maleate, also referred as PNU 95666E or U95666E, is a high affinity D2 receptor full agonist that shows >200-fold selectivity over dopamine receptor ...
NS-2359, a serotonin-norepinephrine-dopamine reuptake inhibitor, may be able to reduce cocaine withdrawal symptoms, reduce cocaine craving and reduce cocaine-in...
Haloperidol (Haldol) is an antipsychotic and butyrophenone.
Fluphenazine DiHCl is the dihydrochloride salt preparation of Fluphenazine. It has been used to deliver Fluphenazine to biological systems in studies probing th...
(R)-Apomorphine Hydrochloride Hemihydrat
(R)-Apomorphine is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.
Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
Lisuride, an indoloquinoline derivative, has been found to be a dopamine D2 receptor agonist and could probably be effective in antimigraine as well as antipark...
SKF-82958 hydrobromide is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. It has characteristic anorectic effects, hyp...