ABT 751 - CAS 141430-65-1
Catalog number: 141430-65-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C18H17N3O4S
Molecular Weight:
371.41
COA:
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Targets:
Microtubule/Tubulin
Description:
ABT 751, also called E7010, is a a novel bioavailable tubulin-binding and antimitotic agent (in neuroblastoma: IC50= 0.6–2.6 μM; in non-neuroblastoma cell lines: IC50=0.7–4.6 μM)
Brife Description:
Binds to β-tubulin; Inhibit microtubule polymerization
Appearance:
Pink solid
Synonyms:
N-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide; E 7010; E-7010; E7010; N-(2-((4-hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide; ABT-751; 141430-65-1; ABT 751; E-7010; ABT751; UNII-WDT5V5OB9F; E 7010; WDT5V5OB9F; CHEMBL20684
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -49℃ for long term (months to years).
MSDS:
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Boiling Point:
551ºC at 760 mmHg
Density:
1.427 g/cm3
InChIKey:
URCVCIZFVQDVPM-UHFFFAOYSA-N
InChI:
1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20)
Canonical SMILES:
COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O
1.Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors.
Kamal A1, Ashraf M, Basha ST, Ali Hussaini SM, Singh S, Vishnuvardhan MV, Kiran B, Sridhar B. Org Biomol Chem. 2016 Jan 28;14(4):1382-94. doi: 10.1039/c5ob02022k. Epub 2015 Dec 16.
A new class of (E)-N-phenyl-3-styrylpyridin-2-amine conjugates were designed and synthesized on the basis of E7010 and resveratrol scaffolds. These conjugates were evaluated for their antiproliferative activity in four human cancer cell lines with GI50 values ranging from 2.1 μM to 20 μM. Two of the conjugates RSV-1 and RSV-11 were found to possess 13-fold higher GI50 values than resveratrol and 1 to 2 fold higher GI50 values than E7010 against the human cervical HepG2 cancer line. They displayed high potency and selectivity in a panel of NCI 60 human cancer cell lines. Based on the GI50 values against the panel of 60 NCI cancer cell lines and dock scores from the molecular modelling studies, we selected RSV-1 and RSV-11 for tubulin polymerization and mechanistic studies. Furthermore, RSV-1 and RSV-11 compounds inhibited the assembly of tubulin by strongly binding to the colchicine-binding site. The G2/M-phase is arrested in HepG2 cells as assessed by flow cytometry.
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CAS 141430-65-1 ABT 751

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