ABT-719 HCl - CAS 162763-53-3
Catalog number: 162763-53-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H21ClFN3O3
Molecular Weight:
381.83
COA:
Inquire
Targets:
Topoisomerase
Description:
The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
ABT-719 HCl; ABT719 HCl; ABT 719 HCl; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligram-Grams
InChIKey:
OMXXLAGAHWXLSP-MERQFXBCSA-N
InChI:
InChI=1S/C18H20FN3O3.ClH/c1-9-15-12(10-2-3-10)6-13(18(24)25)17(23)22(15)8-14(19)16(9)21-5-4-11(20)7-21;/h6,8,10-11H,2-5,7,20H2,1H3,(H,24,25);1H/t11-;/m0./s1
Canonical SMILES:
CC1=C(C(=CN2C1=C(C=C(C2=O)C(=O)O)C3CC3)F)N4CCC(C4)N.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Topoisomerase Products


CAS 97682-44-5 Irinotecan

Irinotecan
(CAS: 97682-44-5)

Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

CAS 100286-90-6 Irinotecan hydrochloride

Irinotecan hydrochloride
(CAS: 100286-90-6)

Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1.

CAS 78186-34-2 Bisantrene

Bisantrene
(CAS: 78186-34-2)

Bisantrene is an anthracenyl bishydrazone used as a particular anticancer drug. Bisantrene can lead to inhibition of DNA replicantion and DNA-protein crosslinki...

CAS 1562067-05-3 Banoxantrone D12

Banoxantrone D12
(CAS: 1562067-05-3)

The deuterium labeled banoxantrone which was rationally designed to have anti-tumor activity following bioreduction by tissue cytochrome P450 to AQ4, an active ...

CAS 174634-08-3 TAS-103

TAS-103
(CAS: 174634-08-3)

TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be ...

CAS 123948-87-8 Topotecan

Topotecan
(CAS: 123948-87-8)

Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. ...

SW044248
(CAS: 522650-83-5)

SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortaliz...

CAS 95343-20-7 Pirarubicin Hydrochloride

Pirarubicin Hydrochloride
(CAS: 95343-20-7)

Pirarubicin Hydrochloride is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. It intercalates into DNA and intera...

CAS 4707-32-8 β-Lapachone

β-Lapachone
(CAS: 4707-32-8)

β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae), exhibiting anti-inflammatory properties by suppr...

CAS 29767-20-2 Teniposide

Teniposide
(CAS: 29767-20-2)

Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).It is in a class of drugs known as podoph...

ABT-719 HCl
(CAS: 162763-53-3)

The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacteria...

CAS 33419-42-0 Etoposide

Etoposide
(CAS: 33419-42-0)

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

CAS 169869-90-3 Exatecan mesylate

Exatecan mesylate
(CAS: 169869-90-3)

Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity...

CAS 169869-90-3 Exatecan Mesylate

Exatecan Mesylate
(CAS: 169869-90-3)

Exatecan Mesylate (DX-8951) is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous sol...

CAS 186668-40-6 (±)-E-Homocamptothecin

(±)-E-Homocamptothecin
(CAS: 186668-40-6)

(±)-E-Homocamptothecin is a potent topoisomerase I (Topo 1) inhibitor.

CAS 71439-68-4 Bisantrene Dihydrochloride

Bisantrene Dihydrochloride
(CAS: 71439-68-4)

Bisantrene Dihydrochloride is the hydrochloride salt of Bisantrene. Bisantrene, also referred to CL-216942, Cyabin or NSC-337766, an anthracene bishydrazone der...

CAS 446-72-0 Genistein

Genistein
(CAS: 446-72-0)

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by ...

CAS 161967-81-3 Grepafloxacin Hydrochloride

Grepafloxacin Hydrochloride
(CAS: 161967-81-3)

The hydrochloride salt form of Grepafloxacin, a fluoroquinolone derivative, has been found to be a Type II DNA topoisomerase inhibitor and was once studied as a...

Tilfrinib
(CAS: 1600515-49-8)

Tilfrinib, a pyridoindol derivative, has been found to be a breast tumor kinase (Brk) inhibitor that could probably restrain the proliferation of breast cancer ...

CAS 65271-80-9 Mitoxantrone

Mitoxantrone
(CAS: 65271-80-9)

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is used in the treatment of certai...

Quick Inquiry

Verification code

Featured Items