|Description||ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis.|
|Current Developer||Abbott Laboratories.|
AT 1015 has been found to be a 5-HT2A receptor antagonist and exhibit antithrombotic activities.
Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 indu...
Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. It is widely used in organ...
NVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively.
Pitolisant hydrochloride is an antagonist of the histamine H3 receptor, which is used for the treatment of narcolepsy with or without cataplexy in adult patient...
Carbazeran is an AO (Aldehyde oxidase) substrate. It is a phosphodiesterase PDE-II and PDE-III inhibitor that can produce concentration-dependent positive inotr...
SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC50 of about 20...
KP496, a novel dual antagonist of cysLT receptor and TP, is currently in clinical development as a dry powder inhaler. KP496 inhibited epithelial hypertrophy an...