ABT-046 - CAS 1031336-60-3
Catalog number: 1031336-60-3
Category: Inhibitor
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ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50=8 nM).
Canonical SMILES:
1.Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.
Yeh VS;Beno DW;Brodjian S;Brune ME;Cullen SC;Dayton BD;Dhaon MK;Falls HD;Gao J;Grihalde N;Hajduk P;Hansen TM;Judd AS;King AJ;Klix RC;Larson KJ;Lau YY;Marsh KC;Mittelstadt SW;Plata D;Rozema MJ;Segreti JA;Stoner EJ;Voorbach MJ;Wang X;Xin X;Zhao G;Collins CA;Cox BF;Reilly RM;Kym PR;Souers AJ J Med Chem. 2012 Feb 23;55(4):1751-7. doi: 10.1021/jm201524g. Epub 2012 Feb 10.
A high-throughput screen against human DGAT-1 led to the identification of a core structure that was subsequently optimized to afford the potent, selective, and orally bioavailable compound 14. Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046.
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CAS 1031336-60-3 ABT-046

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