|Description||ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation.|
|Appearance||white solid powder|
|Synonyms||ABC-294640; ABC 294640; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide.|
|Current Developer||Apogee Biotechnology Corporation.|
MP-A08 is a cell permeable selective inhibitor of sphingosine kinase 2 (Ki=6.9 μM) and 1 (Ki=27 μM) with little affinity for other kinases. In vitro: inhibits c...
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ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon adm...
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K6PC-5 is a Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, an active metabolite of sphingolipid. S1P can...
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