|Description||AB-423 is a small-molecule inhibitor of HBV core protein used to treat chronic HBV infection. In preclinical study, AB-423 was indicated to damage assembly of the viral capsid (IC50 = 3 mcM). In mouse model, it led to a significant reduction of the viral DNA level.|
|Brife Description||inhibitor of HBV, chronic HBV infection|
|Application||the treatment of chronic HBV infection|
|Current Developer||Arbutus Biopharma|
Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names S...
Bay 41-4109 less active enantiomer
Bay 41-4109 less active enantiomer exhibits less activity than Bay 41-4109 that is a novel class of drugs and inhibits hepatitis B virus (HBV) capsid formation ...
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Helioxanthin derivative 5-4-2
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Merimepodib is orally bioavailable IMPDH inhibitor.
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An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.
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AB-423 is a small-molecule inhibitor of HBV core protein used to treat chronic HBV infection. In preclinical study, AB-423 was indicated to damage assembly of t...