A12B4C3 - CAS 1005129-80-5
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
A12B4C3 is a potent and selective inhibitor of polynucleotide kinase/phosphatase (PNKP) (IC50 = 60 nM), a DNA repair enzyme. A12B4C3 is inactive to calcineurin, protein PP-1 or APTX.
Brife Description:
polynucleotide kinase/phosphatase (PNKP) inhibitor
≥98% by HPLC
Canonical SMILES:
1.The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates.
Zereshkian A1, Leyton JV2, Cai Z1, Bergstrom D1, Weinfeld M3, Reilly RM4. Nucl Med Biol. 2014 May-Jun;41(5):377-83. doi: 10.1016/j.nucmedbio.2014.02.003. Epub 2014 Feb 14.
INTRODUCTION: Leukemia stem cells (LSCs) are believed to be responsible for initiating and propagating acute myeloid leukemia (AML) and for causing relapse after treatment. Radioimmunotherapy (RIT) targeting these cells may improve the treatment of AML, but is limited by the low density of target epitopes. Our objective was to study a human polynucleotide kinase/phosphatase (hPNKP) inhibitor that interferes with DNA repair as a radiosensitizer for the Auger electron RIT agent, ¹¹¹In-NLS-7G3, which recognizes the CD123⁺/CD131⁻ phenotype uniquely displayed by LSCs.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


C-telopeptide, also called as CTX, is a cross-linked peptide of type I collagen and an RIA based on monoclonal antibody raised against this 8-amino-acid sequenc...

CAS 1263093-79-3 DL-AP4 Sodium salt

DL-AP4 Sodium salt
(CAS: 1263093-79-3)

The sodium salt form of DL-AP4, which has been found to be a broad spectrum EAA ligand.

CAS 20362-31-6 Arctiin

(CAS: 20362-31-6)

Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, b...

CAS 9041-08-1 Heparin sodium

Heparin sodium
(CAS: 9041-08-1)

Heparin sodium is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease. It is an inhibitor ...

CAS 88898-17-3 Atrial natriuretic factor (1-28) (rat)

Atrial natriuretic factor (1-28) (rat)
(CAS: 88898-17-3)

Atrial natriuretic factor (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendoc...

CAS 65373-29-7 MS 21570

MS 21570
(CAS: 65373-29-7)

MS 21570, a GPR171 antagonist (IC50 = 220 nM), inhibits BigLEN mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basol...

CAS 6877-32-3 Corynoxine

(CAS: 6877-32-3)

Corynoxine is an enantiomer of Corynoxine B. It induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. By inducing autophagy, it p...


TP508, also known as Chrysalin (OrthoLogic, Tempe, Arizona), is a 23 amino acid synthetic peptide representing residues 508-530 of human prothrombin. Studies ha...

Chemical Structure

CAS 1005129-80-5 A12B4C3

Quick Inquiry

Verification code

Featured Items