A01 - CAS 1007647-73-5
Category: Inhibitor
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Molecular Formula:
C22H20ClF3N4O3S
Molecular Weight:
512.93
COA:
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Targets:
Others
Description:
A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM), which attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Study showed that it potentiated BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
Brife Description:
Smurf1 E3 ubiquitin ligase inhibitor
Purity:
≥98% by HPLC
Synonyms:
[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone; SMURF1 inhibitor A01
MSDS:
Inquire
InChIKey:
QFYLTUDRXBNZFQ-UHFFFAOYSA-N
InChI:
InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3
Canonical SMILES:
CC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F
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CAS 1007647-73-5 A01

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