|Description||A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells. It also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice. It has been exhibited to reduce CFA-induced thermal hyperalgesia in a dose-dependent fashion with the ED50 value of 100μmol/kg.|
|Solubility||in DMSO > 10 mM|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||604.9±65.0 °C | Condition: Press: 760 Torr|
|Density||1.45±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flu...
A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20,...
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