A 779 - CAS 159432-28-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C39H60N12O11
Molecular Weight:
872.97
COA:
Inquire
Targets:
Angiotensin Receptor
Description:
A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor) (IC50= 0.3 nM) with no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM.
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Brife Description:
A specific antagonist of G-protein coupled receptor (Mas receptor)
Synonyms:
(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(1R)-1-carboxyethyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid; 7-Ala-angiotensin (1-7); A 778; A 779; A-778; A-779; A779 peptide; angiotensin (1-7), Ala(7)-; angiotensin (1-7), alanyl(7)-; Asp-Arg-Val-Tyr-Ile-His-Ala; aspartyl--arginyl-valyl-tyrosyl-isoleucyl-histidyl-alanine
Solubility:
DMSO: 150 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Density:
1.45±0.1 g/cm3
InChIKey:
GZSZZUXDAPDPOR-NGIFJXEWSA-N
InChI:
1S/C39H60N12O11/c1-6-20(4)31(37(60)49-28(15-23-17-43-18-45-23)34(57)46-21(5)38(61)62)51-35(58)27(14-22-9-11-24(52)12-10-22)48-36(59)30(19(2)3)50-33(56)26(8-7-13-44-39(41)42)47-32(55)25(40)16-29(53)54/h9-12,17-21,25-28,30-31,52H,6-8,13-16,40H2,1-5H3,(H,43,45)(H,46,57)(H,47,55)(H,48,59)(H,49,60)(H,50,56)(H,51,58)(H,53,54)(H,61,62)(H4,41,42,44)/t20-,21+,25-,26-,27-,28-,30-,31-/m0/s1
Canonical SMILES:
CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)NC(C)C(=O)O)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
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Chemical Structure

CAS 159432-28-7 A 779

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