A-1165442 - CAS 1221443-94-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H20ClF2N3O2
Molecular Weight:
431.86
COA:
Inquire
Targets:
TRP Channel
Description:
A-1165442 is a potent, competitive and orally available modality-differentiated second-generation TRPV1 antagonist with good analgesic efficacy and a temperature-neutral profile (IC50= 9 nM for human TRPV1).
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Brife Description:
A potent, competitive and orally available TRPV1 antagonist (IC50= 9 nM for human TRPV1)
Synonyms:
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea; 1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea
Solubility:
DMSO:10 mM
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
574.4±50.0 ℃ at 760 Torr
Density:
1.38±0.1 g/cm3
InChIKey:
VJJGAJAUECQWSZ-LJQANCHMSA-N
InChI:
1S/C22H20ClF2N3O2/c1-13-7-17-14(10-26-13)3-2-4-18(17)27-21(29)28-19-9-22(11-24,12-25)30-20-8-15(23)5-6-16(19)20/h2-8,10,19H,9,11-12H2,1H3,(H2,27,28,29)/t19-/m1/s1
Canonical SMILES:
CC1=NC=C2C=CC=C(C2=C1)NC(=O)NC3CC(OC4=C3C=CC(=C4)Cl)(CF)CF
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 1221443-94-2 A-1165442

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