A 1070722 - CAS 1384424-80-9
Category: Inhibitor
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Molecular Formula:
C17H13F3N4O2
Molecular Weight:
362.31
COA:
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Targets:
GSK-3
Description:
A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such as CDK. It decreases phosphorylation of microtubule-associated protein Tau in vitro. A 1070722 exhibits neuroprotective activity thus is identified as a therapeutic drug candidate for neurodegenerative and psychiatric disorders.
Brife Description:
GSK-3 inhibitor
Purity:
≥99% by HPLC
Synonyms:
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
MSDS:
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Application:
potential treatment of neurodegenerative disorders
InChIKey:
VQPBIJGXSXEOCU-UHFFFAOYSA-N
InChI:
InChI=1S/C17H13F3N4O2/c1-26-10-5-6-11-12(7-8-21-13(11)9-10)22-16(25)24-15-4-2-3-14(23-15)17(18,19)20/h2-9H,1H3,(H2,21,22,23,24,25)
Canonical SMILES:
COC1=CC2=NC=CC(=C2C=C1)NC(=O)NC3=CC=CC(=N3)C(F)(F)F
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Chemical Structure

CAS 1384424-80-9 A 1070722

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