9-Oxoageraphorone - CAS 105181-06-4
Catalog number: 105181-06-4
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Chemical Family:
9-Oxoageraphorone isolated from the herbs of Eupatorium adenophorum.
Publictions citing BOC Sciences Products
  • >> More
> 95%
(1S,4R,4aS,8aR)-1-Isopropyl-4,7-dimethyl-1,3,4,4a,5,8a-hexahydro- 2,6-naphthalenedione
Quality Standard:
Enterprise Standard
1.Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components.
Liu B;Cao L;Zhang L;Yuan X;Zhao B Nat Prod Res. 2017 Dec;31(23):2788-2792. doi: 10.1080/14786419.2017.1292509. Epub 2017 Feb 20.
Eupatorium adenophorum can induce liver toxicity in animals. For the safe utilisation of the weed, the hepatotoxic components need to be discovered. In this study, in vitro hepatotoxicity of different extracts from E. adenophorum were determined on human hepatocyte cell line L02 and hepatocellular carcinoma cell line HepG2. The results showed that water extracts of E. adenophorum exhibited no hepatotoxicity in vitro while high concentrations of the organic solvent extracts had obvious hepatotoxicity. Sesquiterpenes may contribute to the toxicity based on the comparison of composition analysis. Three cadinene sesquiterpenes were purified and identified as 9-oxo-10,11-dehydroageraphorone, 10Hα-9-oxo-ageraphorone and 10Hβ-9-oxo-ageraphorone. In vitro hepatotoxic effects of these components were investigated, the IC;50; of the three compounds were 122.53, 87.52, and 108.80 μM in L02 cells and 151.92, 104.48, and 138.08 μM in HepG2 cells by Cell Counting Kit-8 (CCK-8) assay. The three components were confirmed to be, at least partial, hepatotoxic components.
2.Two New Thymol Derivatives from the Roots of Ageratina adenophora.
Dong LM;Zhang M;Xu QL;Zhang Q;Luo B;Luo QW;Liu WB;Tan JW Molecules. 2017 Apr 8;22(4). pii: E592. doi: 10.3390/molecules22040592.
Two new thymol derivatives, 7,9-diisobutyryloxy-8-ethoxythymol (;1;) and 7-acetoxy-8-methoxy-9-isobutyryloxythymol (;2;), were isolated from fresh roots of ;Ageratina adenophora;, together with four known compounds, 7,9-di-isobutyryloxy-8-methoxythymol (;3;), 9-oxoageraphorone (;4;), (-)-isochaminic acid (;5;) and (1α,6α)-10-hydroxycar-3-ene-2-one (;6;). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the roots of ;A. adenophora; for the first time. All the compounds were tested for their in vitro antibacterial activity toward three Gram-positive and two Gram-negative bacterial strains. Thymol derivatives ;1;-;3; only selectively showed slight in vitro bacteriostatic activity toward three Gram-positive bacteria. The two known carene-type monoterpenes ;5; and ;6; were found to show moderate in vitro antibacterial activity against all five tested bacterial strains, with MIC values from 15.6 to 62.5 μg/mL. In addition, compounds ;5; and ;6; were further revealed to show in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC;50; values ranging from 18.36 to 41.87 μM. However, their cytotoxic activities were inferior to those of reference compound adriamycin.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sesquiterpenoids Products

CAS 109062-00-2 Icariside B1

Icariside B1
(CAS: 109062-00-2)

Icariside B1 can be isolated from the Annona glabra fruit.

CAS 1911-78-0 Oplopanone

(CAS: 1911-78-0)

Oplopanone, a natural sesquiterpenoid found in the herbs of Artemisia sieberi, exhibits the activity of anti-plasmodial effects.

CAS 1445952-30-6 Nardoeudesmol A

Nardoeudesmol A
(CAS: 1445952-30-6)

CAS 1564265-85-5 3,4-Seco-3-oxobisabol-10-ene-4,1-olide

(CAS: 1564265-85-5)

3,4-Seco-3-oxobisabol-10-ene-4,1-olide is isolated from the leaves of Alpinia intermedia.

CAS 97372-53-7 8β-Hydroxycadin-4-en-3-one

(CAS: 97372-53-7)

8β-Hydroxycadin-4-en-3-one is a natural sesquiterpenoid found in the herbs of Eupatorium adenophorum.

(CAS: 1432064-69-1)

CAS 640289-58-3 4(15)-Oppositene-1,7-diol

(CAS: 640289-58-3)

4(15)-Oppositene-1,7-diol is isolated from Artemisia annua.

CAS 213552-47-7 Drim-7-ene-11,12-diol acetonide

Drim-7-ene-11,12-diol acetonide
(CAS: 213552-47-7)

Drim-7-ene-11,12-diol acetonide is a natural sesquiterpenoids isolated from the herbs of Polygonum hydropiper.

CAS 38456-39-2 Deacetyleupaserrin

(CAS: 38456-39-2)

Deacetyleupaserrin is an antileukemic sesquiterpene lactone that is isolated from Eupatorium semiserratum.

8'-Oxo-6-hydroxydihydrophaseic acid
(CAS: 1388075-44-2)

8'-Oxo-6-hydroxydihydrophaseic acid isolated from Illicium dunnianum

CAS 170380-68-4 4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one

(CAS: 170380-68-4)

4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one is isolated from the rhizomes of Curcuma longa.

CAS 393862-19-6 Plucheoside B aglycone

Plucheoside B aglycone
(CAS: 393862-19-6)

CAS 188293-70-1 8α-(2-Methylacryloyloxy)hirsutinolide

(CAS: 188293-70-1)

8α-(2-Methylacryloyloxy)hirsutinolide is isolated from Vernonia cinerea.

CAS 421558-76-1 Artemyriantholide D

Artemyriantholide D
(CAS: 421558-76-1)

Artemyriantholide D is isolated from Artemisia myriantha.

(CAS: 20482-21-7)

8-O-Acetyltorilolone is a natural sesquiterpene compound found in several plants.

Norpterosin B
(CAS: 1226892-20-1)

Norpterosin B is a natural sesquiterpene compound found in several plants.

CAS 63968-64-9 Artemisinin

(CAS: 63968-64-9)

Inhibits tumor necrosis factor-α-induced vascular smooth muscle cell proliferation.

CAS 5986-49-2 Palustrol

(CAS: 5986-49-2)

CAS 76947-60-9 Onitin 2'-O-glucoside

Onitin 2'-O-glucoside
(CAS: 76947-60-9)

Onitin 2'-O-glucoside is a natural sesquiterpenoid found in the herbs of Onychium japonicum.

O-Formylnorpterosin B

O-Formylnorpterosin B is a natural compound found in several plants.

Chemical Structure

CAS 105181-06-4 9-Oxoageraphorone

Quick Inquiry

Verification code

Featured Items