9-Hydroxy-α-lapachone - CAS 22333-58-0
Catalog number: B0005-189981
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Molecular Formula:
C15H14O4
Molecular Weight:
258.3
COA:
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Chemical Family:
Quinones
Description:
9-Hydroxy-α-lapachone isolated from the herbs of Catalpa ovata. It exhibits potent inhibitory activity against H. pylori Cystathionine gamma-synthase.
Ordering Information
Catalog Number Size Price Stock Quantity
B0005-189981 1 mg $399 In stock
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Purity:
96%
Appearance:
Yellow powder
Synonyms:
9-hydroxy-2,2-dimethyl-3,4-dihydrobenzo[g]chromene-5,10-dione
MSDS:
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Application:
potent inhibitory activity
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.Enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from Helicobacter pylori.
Kong Y;Wu D;Bai H;Han C;Chen J;Chen L;Hu L;Jiang H;Shen X J Biochem. 2008 Jan;143(1):59-68. Epub 2007 Nov 1.
Cystathionine gamma-synthase (CGS) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homocysteine in bacteria, whereas this pathway is absent in human. In this report, we identified a new metB gene from Helicobacter pylori strain SS1, and the recombinant H. pylori Cystathionine gamma-synthase (HpCGS) was successfully cloned, expressed and purified in Escherichia coli system. Enzymatic study of HpCGS indicated that the K(m) and k(cat)/K(m) values against the substrate O-succinyl-l-homoserine (l-OSHS) were 3.02 mM and 98.7 M(-)(1)s(-)(1), respectively. Moreover, four natural products (alpha-lapachone, 9-hydroxy-alpha-lapachone, Paulownin and Yangambin, Fig. 1) were discovered to demonstrate inhibitory activities against HpCGS with IC(50) values of 11 +/- 3, 9 +/- 1, 19 +/- 2 and 27 +/- 6 microM, respectively. All these four inhibitors prevent the binding of l-OSHS to HpCGS in a non-competitive fashion. In vitro antibacterial assays further indicated that these four discovered compounds could highly inhibit the growth of H. pylori and exhibited strong inhibitory specificity against H. pylori related to E. coli.
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