9-Dihydro-13-acetylbaccatin III - CAS 142203-65-4
Catalog number: 142203-65-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C33H42O12
Molecular Weight:
630.68
COA:
Inquire
Targets:
Others
Description:
Induces apoptosis. Possible degradation product of taxoid biosynthesis. Anticancer effects.
Purity:
>98%
Synonyms:
9-DHAB III; 13-Acetyl-9-dihydrobaccatin III
MSDS:
Inquire
InChIKey:
WPPPFZJNKLMYBW-FAEUQDRCSA-N
InChI:
InChI=1S/C33H42O12/c1-16-21(42-17(2)34)14-33(40)28(44-29(39)20-11-9-8-10-12-20)26-31(7,22(37)13-23-32(26,15-41-23)45-19(4)36)27(38)25(43-18(3)35)24(16)30(33,5)6/h8-12,21-23,25-28,37-38,40H,13-15H2,1-7H3/t21-,22-,23+,25+,26-,27-,28-,31+,32-,33+/m0/s1
Canonical SMILES:
CC1=C2C(C(C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)O)OC(=O)C
1.Semi-synthesis of an O-glycosylated docetaxel analogue.
Nikolakakis A1, Haidara K, Sauriol F, Mamer O, Zamir LO. Bioorg Med Chem. 2003 Apr 3;11(7):1551-6.
A 7beta-O-glycosylated docetaxel analogue was semi-synthesized from 9-dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis. It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.
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CAS 142203-65-4 9-Dihydro-13-acetylbaccatin III

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