9-Dihydro-13-acetylbaccatin III - CAS 142203-65-4
Catalog number: 142203-65-4
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Induces apoptosis. Possible degradation product of taxoid biosynthesis. Anticancer effects.
9-DHAB III; 13-Acetyl-9-dihydrobaccatin III
Canonical SMILES:
1.Semi-synthesis of an O-glycosylated docetaxel analogue.
Nikolakakis A1, Haidara K, Sauriol F, Mamer O, Zamir LO. Bioorg Med Chem. 2003 Apr 3;11(7):1551-6.
A 7beta-O-glycosylated docetaxel analogue was semi-synthesized from 9-dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis. It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.
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CAS 142203-65-4 9-Dihydro-13-acetylbaccatin III

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