9-Dihydro-13-acetylbaccatin III - CAS 142203-65-4
Catalog number: 142203-65-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C33H42O12
Molecular Weight:
630.68
COA:
Inquire
Targets:
Others
Description:
Induces apoptosis. Possible degradation product of taxoid biosynthesis. Anticancer effects.
Purity:
>98%
Synonyms:
9-DHAB III; 13-Acetyl-9-dihydrobaccatin III
MSDS:
Inquire
InChIKey:
WPPPFZJNKLMYBW-FAEUQDRCSA-N
InChI:
InChI=1S/C33H42O12/c1-16-21(42-17(2)34)14-33(40)28(44-29(39)20-11-9-8-10-12-20)26-31(7,22(37)13-23-32(26,15-41-23)45-19(4)36)27(38)25(43-18(3)35)24(16)30(33,5)6/h8-12,21-23,25-28,37-38,40H,13-15H2,1-7H3/t21-,22-,23+,25+,26-,27-,28-,31+,32-,33+/m0/s1
Canonical SMILES:
CC1=C2C(C(C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)O)OC(=O)C
1.Semi-synthesis of an O-glycosylated docetaxel analogue.
Nikolakakis A1, Haidara K, Sauriol F, Mamer O, Zamir LO. Bioorg Med Chem. 2003 Apr 3;11(7):1551-6.
A 7beta-O-glycosylated docetaxel analogue was semi-synthesized from 9-dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis. It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 23327-57-3 Nefopam Hydrochloride

Nefopam Hydrochloride
(CAS: 23327-57-3)

Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline...

CAS 1618672-71-1 NSC 636819

NSC 636819
(CAS: 1618672-71-1)

NSC 636819 is a KDM4A/KDM4B inhibitor. It induces apoptosis in cultured prostate cancer cells.

CB 966
(CAS: 128312-71-0)

CB 966 is a novel analogues of 1,25-dihydroxyvitamin D3 and it was found to significantly delay the rejection of allogeneic skin grafts in CBA (H-2k) recipient ...

ML 179
(CAS: 1883548-87-5)

ML 179 is a liver receptor homolog 1 inverse agonist with IC50 value of 320 nM.

CAS 3820-67-5 Glafenine

Glafenine
(CAS: 3820-67-5)

Glafenine is a non-steroidal analgesic agent, shows significant antiinflammatory activity.

CAS 905-99-7 Cryptochlorogenic acid

Cryptochlorogenic acid
(CAS: 905-99-7)

Cryptochlorogenic acid is an isomer of chlorogenic acid. It is a natural product extracted from the flowerbud of Lonicera japonica Thunb. It has antioxidant act...

CAS 20263-07-4 DL-AP4

DL-AP4
(CAS: 20263-07-4)

DL-AP4 has been found to be a broad spectrum EAA ligand as well as an NMDA glutamate receptor antagonist.

CAS 27262-48-2 Levobupivacaine hydrochloride

Levobupivacaine hydrochloride
(CAS: 27262-48-2)

Levobupivacaine HCl, the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.

Chemical Structure

CAS 142203-65-4 9-Dihydro-13-acetylbaccatin III

Quick Inquiry

Verification code

Featured Items