6A-methylprednisolone 21-hemisuccinate*sodium - CAS 2375-03-3
Catalog number: 2375-03-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C26H33NaO8
Molecular Weight:
496.53
COA:
Inquire
Targets:
Others
Description:
6α-Methylprednisolone 21-hemisuccinate, a derivative of prednisolone, is a kind of glucocorticoids. It has been developed for having longer half-life than that of Prednisolone and the potential anti-inflammatory effects.
Purity:
≥95%
Appearance:
White to off-white powder
Synonyms:
(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt;6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;6ALPHA-METHYLPREDNISOLONE 21-HEMISUCCINATE
Solubility:
10 mM in H2O
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
6α-Methylprednisolone 21-hemisuccinate is a kind of glucocorticoids and has been found to have potential anti-inflammatory effects.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
234-236 °C
InChIKey:
FQISKWAFAHGMGT-SGJOWKDISA-M
InChI:
InChI=1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1
Canonical SMILES:
CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)[O-])O.[Na+]
1.Patients with Spinal Cord Injuries Favor Administration of Methylprednisolone.
Bowers CA1, Kundu B1, Rosenbluth J2, Hawryluk GW1. PLoS One. 2016 Jan 20;11(1):e0145991. doi: 10.1371/journal.pone.0145991. eCollection 2016.
Methylprednisolone sodium succinate (MPSS) for treatment of acute spinal cord injury (SCI) has been associated with both benefits and adverse events. MPSS administration was the standard of care for acute SCI until recently when its use has become controversial. Patients with SCI have had little input in the debate, thus we sought to learn their opinions regarding administration of MPSS. A summary of the published literature to date on MPSS use for acute SCI was created and adjudicated by 28 SCI experts. This summary was then emailed to 384 chronic SCI patients along with a survey that interrogated the patients' neurological deficits, communication with physicians and their views on MPSS administration. 77 out of 384 patients completed the survey. 28 respondents indicated being able to speak early after injury and of these 24 reported arriving at the hospital within 8 hours of injury. One recalled a physician speaking to them about MPSS and one patient reported choosing whether or not to receive MPSS.
2.A liposomal steroid nano-drug for treating systemic lupus erythematosus.
Moallem E1, Koren E2, Ulmansky R1, Pizov G1, Barlev M2, Barenholz Y2, Naparstek Y3. Lupus. 2016 Mar 7. pii: 0961203316636468. [Epub ahead of print]
BACKGROUND: Glucocorticoids have been known for years to be the most effective therapy in systemic lupus erythematosus. Their use, however, is limited by the need for high doses due to their unfavorable pharmacokinetics and biodistribution. We have previously developed a novel liposome-based steroidal (methylprednisolone hemisuccinate (MPS)) nano-drug and demonstrated its specific accumulation in inflamed tissues, as well as its superior therapeutic efficacy over that of free glucocorticoids (non-liposomal) in the autoimmune diseases, including the adjuvant arthritis rat model and the experimental autoimmune encephalomyelitis mouse model.
3.Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury.
Kim Y1, Jo SH2, Kim WH3, Kweon OK4. Stem Cell Res Ther. 2015 Nov 26;6:229. doi: 10.1186/s13287-015-0236-5.
INTRODUCTION: Mesenchymal stem cells can potentially be used in therapy for spinal cord injury (SCI). Methylprednisolone sodium succinate (MPSS) has been used as a scavenging agent in acute SCI treatment, but its use no longer recommended. This study aimed to identify ways to reduce the usage and risk of high doses of glucocorticoid steroids, and determine whether AD-MSCs could be used as an early alternative treatment modality for acute SCI.
4.A study of methylprednisolone neuroprotection against acute injury to the rat spinal cord in vitro.
Sámano C1, Kaur J2, Nistri A3. Neuroscience. 2016 Feb 19;315:136-49. doi: 10.1016/j.neuroscience.2015.12.003. Epub 2015 Dec 14.
Methylprednisolone sodium succinate (MPSS) has been proposed as a first-line treatment for acute spinal cord injury (SCI). Its clinical use remains, however, controversial because of the modest benefits and numerous side-effects. We investigated if MPSS could protect spinal neurons and glia using an in vitro model of the rat spinal cord that enables recording reflexes, fictive locomotion and morphological analysis of damage. With this model, a differential lesion affecting mainly either neurons or glia can be produced via kainate-evoked excitotoxicity or application of a pathological medium (lacking O2 and glucose), respectively. MPSS (6-10μM) applied for 24h after 1-h pathological medium protected astrocytes and oligodendrocytes especially in the ventrolateral white matter. This effect was accompanied by the return of slow, alternating oscillations (elicited by NMDA and 5-hydroxytryptamine (5-HT)) reminiscent of a sluggish fictive locomotor pattern.
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CAS 2375-03-3 6A-methylprednisolone 21-hemisuccinate*sodium

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