6''-O-Malonylgenistin - CAS 51011-05-3
Catalog number:
51011-05-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H22O13
Molecular Weight:
518.42
COA:
Inquire
Targets:
Others
Description:
6''-O-Malonylgenistin (Malonylgenistin) is an isoflavone derivative.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
Solid powder
Synonyms:
5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl 6-O-(carboxyacetyl)-β-D-glucopyranoside;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A derivative of Genistin. Inhibitor.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
880.2ºC at 760mmHg
Density:
1.654g/cm3
InChIKey:
PELWZARZGNQRCH-ZRYVYJFNSA-N
InChI:
1S/C24H22O13/c25-11-3-1-10(2-4-11)12-8-35-23-14(6-5-13(26)18(23)19(12)30)36-24-22(33)21(32)20(31)15(37-24)9-34-17(29)7-16(27)28/h1-6,8,15,20-22,24-26,31-33H,7,9H2,(H,27,28)/t15-,20-,21+,22-,24-/m1/s1
Canonical SMILES:
c1cc(ccc1c2coc3c(ccc(c3c2=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)COC(=O)CC(=O)O)O)O)O)O
1.Isoflavone content and its potential contribution to the antihypertensive activity in soybean Angiotensin I converting enzyme inhibitory peptides.
Wu J1, Muir AD. J Agric Food Chem. 2008 Nov 12;56(21):9899-904. doi: 10.1021/jf801181a. Epub 2008 Oct 15.
A soybean angiotensin I converting enzyme (ACE) inhibitory peptide fraction was reported to have antihypertensive activity in a rat study. The purpose of the present study was to examine if the presence of isoflavones in the soybean ACE inhibitory peptide fraction may contribute to the blood-pressure-lowering property. The isoflavone concentration in soybean samples was analyzed on a C 18 reverse-phase column using a two-step gradient solvent system. Producing soybean hydrolysate led to a nearly 40% loss of isoflavones compared with the original soybean flour, but the isoflavone composition did not change and the dominant isoflavone chemicals remained as 6''-O-malonylgenistin and 6''-O-malonyldaidzin. Ion exchange chromatography affected significantly both the content and the composition of the isoflavones. The dominant isoflavones in the ion-exchanged fraction were aglycones and nonacylated isoflavones, accounting for 95.8% of the total amount of 987.
2.Multi-response optimisation of the extraction solvent system for phenolics and antioxidant activities from fermented soy flour using a simplex-centroid design.
Handa CL1, de Lima FS2, Guelfi MF3, Georgetti SR4, Ida EI5. Food Chem. 2016 Apr 15;197(Pt A):175-84. doi: 10.1016/j.foodchem.2015.10.124. Epub 2015 Nov 11.
A simplex-centroid design comprising three solvents (water, ethanol and methanol) was used to optimise the extraction mixture for phenolics and antioxidant activities from defatted soy flour fermented with Monascus purpureus or Aspergillus oryzae. Total phenolics were more efficiently extracted using only water for both samples. The highest antioxidant activities by the DPPH and ABTS methods were obtained using extraction mixtures containing at least 75 wt% water. Specific water:ethanol:methanol ratios promoted the joint optimisation of the total phenolic and isoflavone contents as well as antioxidant activities: 0.5:0.375:0.125 (wt/wt/wt) and 0.5:0.3:0.2 (wt/wt/wt) from defatted soy flour fermented with M. purpureus or A. oryzae, respectively. However, a water:ethanol ratio of 0.5:0.5 (wt/wt) was deemed optimal because it is comprised of green solvents and yielded results that were greater than 90% of the multi-response maximum values. Both the solvents and the sample matrix strongly influenced the extractability of total phenolics and isoflavones.
3.Isoflavonoid composition of a callus culture of the relict tree Maackia amurensis Rupr. et Maxim.
Fedoreyev SA1, Bulgakov VP, Grishchenko OV, Veselova MV, Krivoschekova OE, Kulesh NI, Denisenko VA, Tchernoded GK, Zhuravlev YN. J Agric Food Chem. 2008 Aug 27;56(16):7023-31. doi: 10.1021/jf801227q. Epub 2008 Aug 1.
Isoflavonoids, an interesting and restricted group of secondary metabolites of legumes, exhibit estrogenic, antiangiogenic, and anticancer activities and are now popular as dietary supplements. Plant cell cultures that possess an increased ability to synthesize these metabolites were examined. During the investigation, cell cultures of the Far Eastern relict tree Maackia amurensis (Leguminosae) were established. A selection of seed-derived cell aggregates yielded the callus line designated A-18. This culture produces 20 isoflavonoids, namely, the isoflavones genistein, daidzein, formononetin, calycosin, derrone, and pseudobaptigenin and their glycosylated conjugates genistin, 6''-O-malonylgenistin, ononin, 6''-O-malonylononin, daidzin, 3'-methoxydaidzin, 4'-O-beta-D-glucopyranosyldaidzin, 4'-O-beta-D-glucopyranosylgenistin, and 7-O-beta-D-glucopyranosylcalycosin; the pterocarpans maackiain and medicarpin and their glycosylated conjugates 6'-O-malonyl-3-O-beta-D-glucopyranosylmaackiain and 6'-O-malonyl-3-O-beta-D-glucopyranosylmedicarpin; and the new pterocarpan glucoside 6'-O-malonyl-3-O-beta-D-glucopyranosyl-6,6a-dehydromaackiain.
4.The effect of thermal treatment of whole soybean flour on the conversion of isoflavones and inactivation of trypsin inhibitors.
Andrade JC1, Mandarino JM2, Kurozawa LE1, Ida EI3. Food Chem. 2016 Mar 1;194:1095-101. doi: 10.1016/j.foodchem.2015.08.115. Epub 2015 Sep 3.
The aim of this paper was to evaluate the effect of the thermal treatment of whole soybean flour (WSF) on the conversion of isoflavones and the inactivation of trypsin inhibitors. Soybeans were ground and whole soybean flour was obtained and subjected to heat treatment in an oven for 10, 15 and 20min at 100, 150 and 200°C according to a 3(2) experimental design. The response functions were taken to be the contents of different isoflavone forms and the residual activity of trypsin inhibitors. The thermal treatment in the oven altered the content and profile of the different isoflavones forms. At 200°C for 20min, there was a higher conversion of malonylglycosides to acetylglycosides, β-glycosides and aglycones and a significant reduction in the activity of trypsin inhibitors. Mathematical models were established to estimate the process parameters in obtaining the WSF with isoflavone conversions and reductions in trypsin inhibitor activity.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 39262-14-1 Ginsenoside C-K

Ginsenoside C-K
(CAS: 39262-14-1)

Ginsenoside C-K is an intestinal microbiota metabolite of ginsenoside Rb1, which possesses anti-proliferative and anti-inflammatory activities.

CAS 269730-03-2 RPI-1

RPI-1
(CAS: 269730-03-2)

RPI-1 is a cell-permeable, ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. It can also b...

CAS 108427-72-1 AS-35

AS-35
(CAS: 108427-72-1)

AS-35 is used as an antiallergic drug. It controls allergic diseases by inhibiting eosinophil activation.

CAS 142642-31-7 PD 138142

PD 138142
(CAS: 142642-31-7)

PD 138142 is a water soluble Sterol O-acyltransferase inhibitor. Triacylglycerol secretion is decreased in the presence of PD-138142-15. Preclinical development...

CAS 472-26-4 Telocinobufagin

Telocinobufagin
(CAS: 472-26-4)

Telocinobufagin is one of anti-hepatoma constituent in Venenum Bufonis.

CAS 612530-44-6 PTP1B-IN-1

PTP1B-IN-1
(CAS: 612530-44-6)

PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor.

CAS 1613695-14-9 SGC-CBP30

SGC-CBP30
(CAS: 1613695-14-9)

SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Mutations of CREBBP and EP300 lead to...

CAS 500-38-9 Nordihydroguaiaretic acid

Nordihydroguaiaretic acid
(CAS: 500-38-9)

NDGA (Nordihydroguaiaretic acid), also known as masoprocol,  is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea di...

CAS 38976-17-9 α-Tocopherol phosphate

α-Tocopherol phosphate
(CAS: 38976-17-9)

alpha-Tocopherol is the compound demonstrating the highest vitamin E activity, which is available both in its natural form as RRR-alpha-tocopherol isolated from...

CAS 34097-16-0 Clocortolone Pivalate

Clocortolone Pivalate
(CAS: 34097-16-0)

Clocortolone Pivalate is a Corticosteroid Hormone Receptor Agonist. It is used for the treatment of dermatitis and is considered a medium-strength corticosteroi...

GSK-7975A
(CAS: 1253186-56-9)

This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activatio...

Trodusquemine
(CAS: 186139-09-3)

Trodusquemine, also called as MSI-1436 or Aminosterol-1436, with the potential to treat type 2 diabetes and obesity, it is a non-competitive cholestane inihbito...

CAS 110140-89-1 Ridogrel

Ridogrel
(CAS: 110140-89-1)

Ridogrel is a thromboxane synthase inhibitor used for the prevention of systemic thrombo-embolism. It is also a receptor antagonist that may be used as an adjun...

CAS 3820-67-5 Glafenine

Glafenine
(CAS: 3820-67-5)

Glafenine is a non-steroidal analgesic agent, shows significant antiinflammatory activity.

CAS 136-77-6 4-Hexylresorcinol

4-Hexylresorcinol
(CAS: 136-77-6)

4-Hexylresorcinol, a phenol derivative, could be commonly used as antioxidant, vermifuge and food additives.

CAS 343306-79-6 Sugammadex

Sugammadex
(CAS: 343306-79-6)

Sugammadex, a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periphery, is an agent for reversal of neuromuscular blockade by the agent rocu...

MRT-92
(CAS: 1428315-82-5)

BMS779333
(CAS: 1095181-60-4)

BMS779333 is a novel AR pan-antagonist with significantly improved cardiovascular and metabolic profiles. It has anti- tumor effect.

CAS 1037184-44-3 YK-4-279

YK-4-279
(CAS: 1037184-44-3)

YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA ...

CAS 130641-38-2 Bindarit

Bindarit
(CAS: 130641-38-2)

Bindarit treatment inhibits the release of MCP-1 from IL-1 stimulated osteoblast cell line Saos-2.

Chemical Structure

CAS 51011-05-3 6''-O-Malonylgenistin

Quick Inquiry

Verification code

Featured Items