6-Iodonordihydrocapsaicin - CAS 859171-97-4
Category: Inhibitor
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Molecular Formula:
C17H26INO3
Molecular Weight:
419.30
COA:
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Description:
6-Iodonordihydrocapsaicin is a potent and competitive vanilloid TRPV1 (VR1) receptor antagonist with IC50 value of 10 nM. It inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons. It also inhibits guinea pig bladder and trachea contractions in vitro. It may induce luciferase gene expression.
Purity:
≥99% by HPLC
Synonyms:
N-[(4-Hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide; 6-​I-​CPS
MSDS:
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InChIKey:
AAORACFZMYMFCG-UHFFFAOYSA-N
InChI:
InChI=1S/C17H26INO3/c1-3-4-5-6-7-8-9-17(21)19-12-13-10-16(22-2)15(20)11-14(13)18/h10-11,20H,3-9,12H2,1-2H3,(H,19,21)
Canonical SMILES:
CCCCCCCCC(=O)NCC1=CC(=C(C=C1I)O)OC
1.Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.
Kang DW;Kim YS;Lim KS;Kim MS;Pearce LV;Pavlyukovets VA;Tao AK;Lang-Kuhs KA;Blumberg PM;Lee J Bioorg Med Chem. 2010 Nov 15;18(22):8092-105. doi: 10.1016/j.bmc.2010.09.001. Epub 2010 Sep 18.
As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3-methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I>Br>Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 and 75 showed the most potent antagonism, with K(i) (ant)=2.77 and 2.19nM, respectively, on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6'-iodononivamide.
2.The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938.
Perez-Burgos A;Wang L;McVey Neufeld KA;Mao YK;Ahmadzai M;Janssen LJ;Stanisz AM;Bienenstock J;Kunze WA J Physiol. 2015 Sep 1;593(17):3943-57. doi: 10.1113/JP270229. Epub 2015 Jul 20.
Certain probiotic bacteria have been shown to reduce distension-dependent gut pain, but the mechanisms involved remain obscure. Live luminal Lactobacillus reuteri (DSM 17938) and its conditioned medium dose dependently reduced jejunal spinal nerve firing evoked by distension or capsaicin, and 80% of this response was blocked by a specific TRPV1 channel antagonist or in TRPV1 knockout mice. The specificity of DSM action on TRPV1 was further confirmed by its inhibition of capsaicin-induced intracellular calcium increases in dorsal root ganglion neurons. Another lactobacillus with ability to reduce gut pain did not modify this response. Prior feeding of rats with DSM inhibited the bradycardia induced by painful gastric distension. These results offer a system for the screening of new and improved candidate bacteria that may be useful as novel therapeutic adjuncts in gut pain. Certain bacteria exert visceral antinociceptive activity, but the mechanisms involved are not determined. Lactobacillus reuteri DSM 17938 was examined since it may be antinociceptive in children. Since transient receptor potential vanilloid 1 (TRPV1) channel activity may mediate nociceptive signals, we hypothesized that TRPV1 current is inhibited by DSM.
3.Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice.
Mascarenhas DC;Gomes KS;Sorregotti T;Nunes-de-Souza RL Front Pharmacol. 2017 Oct 4;8:695. doi: 10.3389/fphar.2017.00695. eCollection 2017.
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures. For instance, the stimulation of both Transient Receptor Potential Vanilloid type 1 (TRPV1) and Cannabinoid type 1 (CB1) receptors led to paradoxical effects on nociception. Here, we attempted to propose a clear and reproducible methodology to achieve the antinociceptive effect of exogenous AEA within the dorsal periaqueductal gray (dPAG) of mice exposed to the tail-flick test. Accordingly, male Swiss mice received intra-dPAG injection of AEA (CB1/TRPV1 agonist), capsaicin (TRPV1 agonist), WIN (CB1 agonist), AM251 (CB1 antagonist), and 6-iodonordihydrocapsaicin (6-IODO) (TRPV1 selective antagonist) and their nociceptive response was assessed with the tail-flick test. In order to assess AEA effects on nociception specifically at vanilloid or cannabinoid (CB) substrates into the dPAG, mice underwent an intrinsically inactive dose of AM251 or 6-IODO followed by local AEA injections and were subjected to the same test. While intra-dPAG AEA did not change acute pain, local injections of capsaicin or WIN induced a marked TRPV1- and CB1-dependent antinociceptive effect, respectively.
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CAS 859171-97-4 6-Iodonordihydrocapsaicin

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