6-Hydroxyrubiadin - CAS 87686-86-0
Catalog number: 87686-86-0
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6-Hydroxyrubiadin is a natural anthraquinone found in the roots of Rubia cordifolia L.
Orange powder
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1.Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots.
Deng Y;Chin YW;Chai H;Keller WJ;Kinghorn AD J Nat Prod. 2007 Dec;70(12):2049-52. Epub 2007 Dec 13.
Two new benzophenones, morintrifolins A ( 1) and B ( 2), together with 14 known anthraquinones and four other known compounds, were isolated from a chloroform-soluble extract of Morinda citrifolia roots. Of the isolated compounds, four known anthraquinones, namely, 1,2-dihydroxyanthraquinone ( 3), 1,3-dihydroxy-2-methylanthraquinone ( 4), 2-hydroxy-3-(hydroxymethyl)anthraquinone ( 5), and 1,3,6-trihydroxy-2-methylanthraquinone ( 6), exhibited quinone reductase (QR)- inducing activity in Hepa lclc7 cells, with concentrations required to double QR activity of 12.0, 8.1, 0.94, and 0.56 microM, respectively.
2.Evaluation of analgesic and anti-inflammatory activities of Rubia cordifolia L. by spectrum-effect relationships.
Shen CH;Liu CT;Song XJ;Zeng WY;Lu XY;Zheng ZL;Jie-Pan;Zhan RT;Ping-Yan J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 15;1090:73-80. doi: 10.1016/j.jchromb.2018.05.021. Epub 2018 May 17.
The objective of the current work was to evaluate the spectrum-effect relationships between high-performance liquid chromatography fingerprints and analgesic and anti-inflammatory effects of Rubia cordifolia L. extract (RCE), and to identify active components of RCE. Chemical fingerprints of ten batches of RC from various sources were obtained by HPLC, and similarity and hierarchical clustering analyses were carried out. Pharmacodynamic assays were performed in adjuvant-induced arthritis rat model to assess the analgesic and anti-inflammatory properties of RCE. The spectrum-effect relationships between chemical fingerprints and the analgesic and anti-inflammatory effects of RCE were established by gray correlation analysis. UPLC-ESI-MS was used to identify the structures of potential active components, by reference standards comparison. The results showed that a close correlation existed between chemical fingerprints with analgesic and anti-inflammatory activities, and alizarin, 6-hydroxyrubiadin, purpurin and rubiadin might be the active constituents of RCE. In addition, RCE attenuated pathological changes in adjuvant-induced arthritis. The current findings provide a strong basis for combining chemical fingerprints with analgesic and anti-inflammatory activities in assessing the spectrum-effect relationships of RCE.
3.Rosenones A and B, new anthraquinone derivatives from Aitchisonia rosea.
Noor AT;Begum A;Anis I;Parveen S;Malik A;Tareen RB J Asian Nat Prod Res. 2009;11(3):209-12. doi: 10.1080/10286020802696403.
Rosenones A (1) and B (2), new anthraquinone derivatives, have been isolated from the ethyl acetate soluble fraction of Aitchisonia rosea along with 1,3,6-trihydroxy-2-methylanthraquinone (3) reported for the first time from this species.
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CAS 87686-86-0 6-Hydroxyrubiadin

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