6-Azauracil - CAS 461-89-2
Catalog number: 461-89-2
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C3H3N3O2
Molecular Weight:
113.07
COA:
Inquire
Targets:
Others
Description:
6-Azauracil inhibits enzymes in nucleoside synthesis and depletes the intracellular GTP/UTP pool. It is being used to identify mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways.
Purity:
≥98%
Appearance:
White solid.
Synonyms:
6-Azauracil;461-89-2;1,2,4-Triazine-3,5(2H,4H)-dione;Azauracil;1,2,4-Triazine-3,5-diol;4(6)-Azauracil
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Inhibits enzymes in nucleoside synthesis and depletes the intracellular GTP/UTP pool
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
Boiling Point:
503.4ºC at 760 mmHg
Melting Point:
276-280 ºC
Density:
1.86 g/cm3
InChIKey:
SSPYSWLZOPCOLO-UHFFFAOYSA-N
InChI:
1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
Canonical SMILES:
C1=NNC(=O)NC1=O
1.Potential antineoplastics I: substituted 3,5-dioxo-and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines.
Ibrahim el-SA, Shams el-Dine SA, Soliman FS, Labouta IM. J Pharm Sci. 1979 Feb;68(2):243-5.
The synthesis of some 6-substituted 3,5-dioxo- and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines for possible antineoplastic activity is reported. The assigned structures were substantiated by IR, NMR, and mass spectral studies of representative members of the series. Four compounds were tested against P-388 lymphocytic leukemia and were inactive.
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CAS 461-89-2 6-Azauracil

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