6-Aminoquinoline-N-hydroxy-succinimidyl carbamate - CAS 148757-94-2
Catalog number: B0001-289971
Category: Main Product
Molecular Formula:
Molecular Weight:
Certificate of Analysis-6-Aminoquinoline-N-hydroxy-succinimidyl carbamate 148757-94-2 B15Z1205  
6-Aminoquinoline-N-hydroxy-succinimidyl carbamate is suitable for amino acid or protein sequence analysis by HPLC with fluorescence detection.
Ordering Information
Catalog Number Size Price Stock Quantity
B0001-289971 100 mg $199 In stock
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Brife Description:
AQC is used in analysis of amino acids or protein sequence by HPLC with fluorescence detection.
≥ 97.0%
White to Yellow Solid
AQC; AHC reagent; AccQ.Fluor; AccQ·Tag
DMSO (Slightly), Methanol (Slightly, Heated)
Stored at -20°C.
6-Aminoquinoline-N-hydroxy-succinimidyl carbamate is used as derivatization regent for detecting hydrogen cyanamide in fruit.
Quality Standard:
In-house Standard
Shelf Life:
Stable for at least 2 years after receipt when stored properly.
Melting Point:
1.48 g/cm3
1.Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates.
Heller L, Perl V, Wiemann J, Al-Harrasi, Csuk R. Bioorg Med Chem Lett. 2016 Apr 20. pii: S0960-894X(16)30431-0. doi: 10.1016/j.bmcl.2016.04.055. [Epub ahead of print]
While 3-O-acetylated betulin derivatives carrying a carbamate moiety at position C-28 are of rather low cytotoxicity for human tumor cell lines, the corresponding C-3 amino(oxo) acetates show good cytotoxicity. For example, an EC50 as low as 2.0μM was found for (3β) 28-{[(hexylamino)carbonyl]oxy}lup-20(29)-en-3-yl amino(oxo)acetate (16) employing the ovarian cancer cell line A2780.
2.The P450 CYP6Z1 confers carbamate/pyrethroid cross-resistance in a major African malaria vector beside a novel carbamate-insensitive N485I acetylcholinesterase-1 mutation.
Ibrahim SS, Ndula M, Riveron JM, Irving H, Wondji CS. Mol Ecol. 2016 May 2. doi: 10.1111/mec.13673. [Epub ahead of print]
Carbamates are increasingly used for vector control notably in areas with pyrethroid resistance. However, a cross-resistance between these insecticides in major malaria vectors such as Anopheles funestus could severely limit available resistance management options. Unfortunately, the molecular basis of such cross-resistance remains uncharacterized in An. funestus, preventing effective resistance management. Here, using a genome-wide transcription profiling, we revealed that metabolic resistance through up-regulation of cytochrome P450 genes is driving carbamate resistance. The P450s CYP6P9a, CYP6P9b and CYP6Z1 were the most up-regulated detoxification genes in the multiple resistant mosquitoes. However, in silico docking simulations predicted CYP6Z1 to metabolise both pyrethroids and carbamates, whereas CYP6P9a and CYP6P9b were predicted to metabolise only the pyrethroids. Using recombinant enzyme metabolism and inhibition assays we demonstrated that CYP6Z1 metabolizes bendiocarb and pyrethroids, whereas CYP6P9a and CYP6P9b metabolise only the pyrethroids. Other up-regulated gene families in resistant mosquitoes included several cuticular protein genes suggesting a possible reduced penetration resistance mechanism. Investigation of the target-site resistance in acetylcholinesterase 1 (ace-1) gene detected and established the association between the new N485I mutation and bendiocarb resistance (Odds ratio 7.3; P<0.0001). The detection of multiple haplotypes in single mosquitoes after cloning suggested the duplication of ace-1. A TaqMan genotyping of the N485I in nine countries revealed that the mutation is located only in Southern Africa with frequency of 10-15% suggesting its recent occurrence. These findings will help in monitoring the spread and evolution of carbamate resistance and improve the design of effective resistance management strategies to control this malaria vector. This article is protected by copyright. All rights reserved.
3.Light Induced C-C Coupling of 2-Chlorobenzazoles with Carbamates, Alcohols, and Ethers.
Lipp A, Lahm G, Opatz T. J Org Chem. 2016 Apr 29. [Epub ahead of print]
A light induced, transition metal-free C-C coupling reaction of 2-chlorobenzazoles with aliphatic carbamates, alcohols, and ethers is presented. Inexpensive reagents, namely sodium acetate, benzophenone, water, and acetonitrile are employed in a simple reaction protocol using a cheap and widely available 25 W energy saving UV-A lamp at ambient temperature.
4.[Condition optimization for bio-oxidation of high-S and high-As gold concentrate].
Yang C, Dong B, Wang M, Ye Z, Zheng T, Huang H. Wei Sheng Wu Xue Bao. 2015 Dec 4;55(12):1626-34.
OBJECTIVE: To study the effects of temperature and lixivium return on the concentrate bio-oxidation and rate of gold cyanide leaching.
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CAS 148757-94-2 6-Aminoquinoline-N-hydroxy-succinimidyl carbamate

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