6-Acetamidohexanoic acid - CAS 57-08-9
Catalog number: 57-08-9
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
6-Acetamidohexanoic acid is used in inhibiting the Gastrointestinal disease like gastric ulcer or small bowel inflammation. It is often used after some oral administration of ZAC(zinc acexamate), an antiulcer agent.
> 97%
White to Off-White Solid
6-(Acetylamino)hexanoic Acid; 6-Acetamidocaproic Acid; Acemin; Acetaminocaproic Acid; Acexamic Acid; CY 153; N-Acetyl-6-aminohexanoic Acid; AACA; N-Acetyl-ε-aminocaproic Αcid; NSC 12945; ε-Acetamidocaproic Acid
DMSO: > 1.8 mg/mL
-20°C Freezer
6-Acetamidohexanoic acid is used in inhibiting the Gastrointestinal disease like gastric ulcer or small bowel inflammation
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Melting Point:
100-103 ºC
Canonical SMILES:
1.[Protection by zinc acexamate against gastric lesions induced by non-steroid anti-inflammatory agents].
Navarro C;Bravo L;Bulbena O Rev Esp Enferm Dig. 1993 Mar;83(3):156-60.
The ability of different non-steroidal anti-inflammatory drugs (diclofenac, indomethacin, ketoprofen, naproxen and piroxicam) to inhibit gastric prostaglandin E2 production in the rat was compared with their damaging potential on gastric mucosa. The influence of treatment with zinc acexamate (ZAC) on these two parameters was also determined. ZAC treatment significantly decreased the degree of gastric damage elicited by all the antiinflammatories tested. The experimental data confirm the complexity of the gastrolesive effect exerted by anti-inflammatory drugs and that only part of such effect would be related with their inhibition of prostaglandin synthesis. These results indicate that the gastroprotection of ZAC does not exclusively depend on the effect on the synthesis of prostaglandins by the gastric mucosa, yet it can additionally be exerted through alternative mechanisms.
2.ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation.
Lee U;Choi YH;Kim YG;Lee BK;Oh E;Lee MG Xenobiotica. 2012 Mar;42(3):310-5. doi: 10.3109/00498254.2011.619014. Epub 2011 Oct 12.
The pharmacokinetics of ϵ-acetamidocaproic acid (AACA) were evaluated after the intravenous and oral administration of an antiulcer agent, zinc acexamate (ZAC) at a dose of 20 mg kg⁻¹ (ion pairing between zinc and AACA) in rats with indomethacin-induced acute gastric ulcer (IAGU) or indomethacin-induced small bowel inflammation (ISBI). In IAGU rats, the area under the curves (AUCs) of AACA were significantly smaller after both the intravenous (551 versus 1270 μg min ml⁻¹) and oral (397 versus 562 μg min ml⁻¹) administration of ZAC than controls, possible due to the significantly faster CL(R) of AACA. In ISBI rats, however, the AUCs of AACA were comparable with controls after both the intravenous and oral administration of ZAC. In IAGU rats, the significantly smaller AUCs of AACA were due to the significantly faster CL(R) (due to the decreased urinary pH by indomethacin treatment) than controls. AACA has a basic secondary amine group. On the other hand, the comparable AUCs of AACA in ISBI rats were due to the comparable CL(R)s between ISBI and control rats. AACA was excreted in the urine via active renal tubular secretion in all rats studied.
3.Identification of metabolites of the cell-differentiating agent hexamethylene bisacetamide in humans.
Callery PS;Egorin MJ;Geelhaar LA;Nayar MS Cancer Res. 1986 Oct;46(10):4900-3.
Hexamethylene bisacetamide, a compound which in vitro induces differentiation in a wide variety of human and animal cancer cell lines, is being investigated in phase I clinical trials. After i.v. administration of hexamethylene bisacetamide to humans, urine contained the parent compound and at least five metabolites formed by deacetylation and oxidation pathways. Identification of urinary metabolites was accomplished by gas chromatography-mass spectrometric analysis after isolation by ion exchange chromatography or extraction with ethyl acetate. Metabolites with amino or alcohol groups were trifluoroacetylated and acidic functional groups were esterified with 2,2,2-trifluoroethanol or methanol. The structure of each metabolite was confirmed by comparison with authentic standards. Metabolites identified included the major metabolite, 6-acetamidohexanoic acid; the monodeacetylated product, N-acetyl-1,6-diaminohexane; the bis-deacetylated diamine, 1,6-diaminohexane; and the amino acid, 6-aminohexanoic acid and its lactam, caprolactam.
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CAS 57-08-9 6-Acetamidohexanoic acid

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