5-hydroxypyrazine-2-carboxylic acid - CAS 34604-60-9
Catalog number: 34604-60-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C5H4N2O3
Molecular Weight:
140.1
COA:
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Targets:
Antibacterial
Description:
A versatile building block for the synthesis of new antituberculous agents. A metabolite of Pyrazinamide.
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Purity:
>98%
Synonyms:
4,5-Dihydro-5-oxopyrazinecarboxylic Acid; 5-Hydroxypyrazinecarboxylic Acid; 5-Hydroxypyrazinoic acid; 5-Oxo-4,5-dihydropyrazine-2-carboxylic Acid
MSDS:
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1.Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide
C. BECKER, J.B. DRESSMAN. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 97, NO. 9, SEPTEMBER 2008
The purpose and scope of this series of monographs have been previously discussed. Summarized in few words, the aim is to evaluate all pertinent data available from literature sources for a given API to assess the risks associated with a biowaiver. For these purposes, risk is defined as the probability of an incorrect biowaiver decision as well as the consequences of the decision in terms of public health and individual patient risks. On the basis of these considerations, a recommendation can be made as to whether a biowaiver approval is advisable or not. This systematic approach to recommend or advise against a biowaiver decisions is referred to in the recently published World Health Organization (WHO) Guideline. It is pointed out that these monographs do not simply apply this WHO Guideline, nor the FDA and/or EMEA Guidance, but also want to serve as a critical validation of these regulatory documents. Biowaiver monographs have already been published for acetaminophen (INN: paracetamol), amitriptyline, atenolol, chloroquine, cimetidine, ethambutol, ibuprofen, isoniazid, prednisolone, prednisone, propranolol, ranitidine, and verapamil. They are also available online at the website of the International Pharmaceutical Federation FIP.
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CAS 34604-60-9 5-hydroxypyrazine-2-carboxylic acid

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