5α-Hydroxycostic acid - CAS 132185-83-2
Catalog number: 132185-83-2
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H22O3
Molecular Weight:
250.3
COA:
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Chemical Family:
Sesquiterpenoids
Description:
5α-Hydroxycostic acid isolated from the roots of Aucklandia lappa Decne.
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Purity:
0.965
Appearance:
Powder
Synonyms:
5-hydroxyeudesma-4(15),11(13)-dien-12-oic acid; 2-[(2R,4aR,8aR)-8a-Hydroxy-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid
MSDS:
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Application:
anti-inflammatory activity
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways.
Liang N;Li Y;Chung HY Int J Oncol. 2017 Jul;51(1):213-222. doi: 10.3892/ijo.2017.4004. Epub 2017 May 17.
Eudesmane-type sesquiterpenes are natural sesquiterpenes with anti-inflammatory properties, but their anti-angiogenic activities are not known. The present study demonstrated that 5α-hydroxycostic acid and hydroxyisocostic acid, two eudesmane-type sesquiterpenes (ETSs), isolated from the herb Laggera alata, possessed anti-angiogenic effects. Under non-toxic dosage, ETSs suppressed VEGF‑induced proliferation in human umbilical vein endothelial cells (HUVECs) and vessel formation in zebrafish embryos. Moreover, ETSs inhibited VEGF-stimulated HUVEC migration, stress fibers and tube formation. Results from real‑time PCR analysis involving in vivo and in vitro experiments indicated that pro-angiogenic-related mRNA levels were downregulated, including VEGFA, VEGFR2 and Tie2 genes after ETS treatments. Western blot analysis showed that ETSs suppressed VEGF-stimulated VEGFR2 phosphorylation and activation of its downstream molecules, such as Src/AKT/eNOS, FAK, PLCγ/ERK1/2 and p38. Moreover, the VEGF-stimulation of angiopoietin 2 (Ang2) mRNA level increase was significantly downregulated in the presence of ETSs. ETSs inhibited Ang2-induced phosphorylation of the receptor Tie2 in HUVECs, which indicated that ETSs not just suppressed VEGF/VEGFR2 axis, but also the Ang2/Tie2 one.
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CAS 132185-83-2 5α-Hydroxycostic acid

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