5,7-Diiodo-8-Quinolinol - CAS 83-73-8
Catalog number: 83-73-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
5,7-Diiodo-8-Quinolinol is a topical therapeutic agent with satisfactory antibacterial properties. It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism. It is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is used in the treatment of amoebiasis. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. It was discovered by Adco Co.
Yellow to Tan Powder or Crystals
10 mM in DMSO
-20°C Freezer
5,7-Diiodo-8-Quinolinol is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is used in the treatment of amoebiasis. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis.
Quality Standard:
USP standard
Shelf Life:
2 month in rt, long time
Kilogram to ton
Boiling Point:
401.8±45.0 °C | Condition: Press: 760 Torr
Melting Point:
210 °C
2.491±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
Current Developer:
5,7-Diiodo-8-Quinolinol was discovered by Adco Co.
1.Oral treatment of acrodermatitis enteropathica with zinc sulfate.
Der Kaloustian VM;Musallam SS;Sanjad SA;Murib A;Hammad WD;Idriss ZH Am J Dis Child. 1976 Apr;130(4):421-3.
In a 7-year-old boy with acrodermatitis enteropathica, oral administration of zinc sulfate brought about complete relief of symptoms and signs, with clearing of the skin lesions, arrest of diarrhea, and growth of new hair. Considering the dramatic results obtained, we believe that oral treatment with zinc sulfate is an innocuous, inexpensive, and very effective medication for acrodermatitis enteropathica, which can replace the previously used and toxic diiodohydroxyquin-like drugs.
2.Treatment of acrodermatitis enteropathica with zinc sulfate.
Campo AG Jr;McDonald CJ Arch Dermatol. 1976 May;112(5):687-9.
Control of a case of acrodermatitis enteropathica was achieved initially after three months of treatment with diiodohydroxyquin (Diodoquin). Reexacerbation of acrodermatitis enteropathica was noted two months after diiodohydroxyquin was discontinued. Treatment with zinc sulfate was substituted and resulted in dramatic and complete resolution of disease within 48 hours.
3.A review of the clinical presentation of dientamoebiasis.
Stark D;Barratt J;Roberts T;Marriott D;Harkness J;Ellis J Am J Trop Med Hyg. 2010 Apr;82(4):614-9. doi: 10.4269/ajtmh.2010.09-0478.
Among 750 symptomatic and asymptomatic patients, Dientamoeba fragilis was detected at a prevalence of 5.2% and more common than Giardia intestinalis. Most infected patients presented with diarrhea and abdominal pain with symptoms greater than 2 weeks duration being common. Bacterial and viral causes of infection were excluded by routine microbiological techniques. Treatment of D. fragilis infection with either iodoquinol, paromomycin, or combination therapy resulted in the eradication of the parasite and complete resolution of symptoms. Treatment failure/relapses were associated only with the use of metronidazole. Nineteen patients were examined for pin worm, no Enterobius vermicularis, a proposed vector of transmission, were detected. Intermittent shedding of D. fragilis was found to be highly variable. These studies confirm the pathogenic nature of D. fragilis and we recommend laboratories routinely test for the organism.
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CAS 83-73-8 5,7-Diiodo-8-Quinolinol

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