4SC-207 - CAS 871015-11-1
Catalog number: 871015-11-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H18N4O3S
Molecular Weight:
382.43622
COA:
Inquire
Purity:
>98%
Appearance:
white solid powder
Synonyms:
4SC207; 4SC-207; 4SC 207
MSDS:
Inquire
1.A novel microtubule inhibitor 4SC-207 with anti-proliferative activity in taxane-resistant cells.
Bausch E1, Kohlhof H, Hamm S, Krauss R, Baumgartner R, Sironi L. PLoS One. 2013 Nov 6;8(11):e79594. doi: 10.1371/journal.pone.0079594. eCollection 2013.
Microtubule inhibitors are invaluable tools in cancer chemotherapy: taxanes and vinca alkaloids have been successfully used in the clinic over the past thirty years against a broad range of tumors. However, two factors have limited the effectiveness of microtubule inhibitors: toxicity and resistance. In particular, the latter is highly unpredictable, variable from patient to patient and is believed to be the cause of treatment failure in most cases of metastatic cancers. For these reasons, there is an increasing demand for new microtubule inhibitors that can overcome resistance mechanisms and that, at the same time, have reduced side effects. Here we present a novel microtubule inhibitor, 4SC-207, which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 90-45-9 9-Aminoacridine

9-Aminoacridine
(CAS: 90-45-9)

9-Aminoacridine is a highly fluorescent dye, an acridine analog. It is used clinically as a topical antiseptic and experimentally as a mutagen. It is an intrace...

CAS 862507-23-1 LY2228820 dimesylate

LY2228820 dimesylate
(CAS: 862507-23-1)

LY2228820 dimesylate is a highly selective small molecule inhibitor of p38α(IC50=7 nM) and p38β mitogen-activated protein kinases (MAPKs).

CAS 31932-87-3 (RS)-3-Hydroxyphenylglycine

(RS)-3-Hydroxyphenylglycine
(CAS: 31932-87-3)

(RS)-3-Hydroxyphenylglycine is an agonist at PI-linked metabotropic glutamate receptors.

CAS 20012-08-2 Trimopam

Trimopam
(CAS: 20012-08-2)

Trimopam is a dopamine receptor agonist.

CAS 865773-15-5 PF-03084014

PF-03084014
(CAS: 865773-15-5)

PF-03084014 is a selective gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor PF-03084014 binds to GS, blocking proteol...

CAS 267243-28-7 Canertinib

Canertinib
(CAS: 267243-28-7)

Canertinib (CI-1033) is an experimental drug candidate for the treatment of cancer. It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (...

CAS 135701-69-8 N-Acetylglycyl-D-glutamic acid

N-Acetylglycyl-D-glutamic acid
(CAS: 135701-69-8)

N-Acetylglycyl-D-glutamic acid is a kind of excitatory peptide. It is more potent than L-glutamic acid at inducing seizures in mice.

CAS 119515-38-7 Picaridin

Picaridin
(CAS: 119515-38-7)

Picaridin,also known as Icaridin, KBR 3023, under the INCI name hydroxyethyl isobutyl piperidine carboxylate, and the trade names Bayrepel and Saltidin, is an i...

Chemical Structure

CAS 871015-11-1 4SC-207

Quick Inquiry

Verification code

Featured Items