4-Trifluoromethylphenylboronic acid - CAS 128796-39-4
Catalog number: 128796-39-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
4-(Trifluoromethyl)phenylboronic acid is a very useful building block for chemical synthesis
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white powder
Soluble in DMSO
-20°C Freezer
building block for chemical synthesis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Boiling Point:
258.6ºC at 760 mmHg
Melting Point:
Canonical SMILES:
1.Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis.
Gonçalves-de-Albuquerque CF1, Medeiros-de-Moraes IM1, Oliveira FM1, Burth P2, Bozza PT1, Castro Faria MV3, Silva AR1, Castro-Faria-Neto HC1,4. PLoS One. 2016 Apr 14;11(4):e0153607. doi: 10.1371/journal.pone.0153607.
Sepsis is characterized by inflammatory and metabolic alterations, which lead to massive cytokine production, oxidative stress and organ dysfunction. In severe systemic inflammatory response syndrome, plasma non-esterified fatty acids (NEFA) are increased. Several NEFA are deleterious to cells, activate Toll-like receptors and inhibit Na+/K+-ATPase, causing lung injury. A Mediterranean diet rich in olive oil is beneficial. The main component of olive oil is omega-9 oleic acid (OA), a monounsaturated fatty acid (MUFA). We analyzed the effect of OA supplementation on sepsis. OA ameliorated clinical symptoms, increased the survival rate, prevented liver and kidney injury and decreased NEFA plasma levels in mice subjected to cecal ligation and puncture (CLP). OA did not alter food intake and weight gain but diminished reactive oxygen species (ROS) production and NEFA plasma levels. Carnitine palmitoyltransferase IA (CPT1A) mRNA levels were increased, while uncoupling protein 2 (UCP2) liver expression was enhanced in mice treated with OA.
2.Neurochemical Changes Associated with Stress-Induced Sleep Disturbance in Rats: In Vivo and In Vitro Measurements.
Lee DW1,2, Chung S3, Yoo HJ4, Kim SJ4, Woo CW2, Kim ST2, Lee DH1, Kim KW5, Kim JK5, Lee JS5, Choi CG5, Shim WH5, Choi Y2, Woo DC2. PLoS One. 2016 Apr 14;11(4):e0153346. doi: 10.1371/journal.pone.0153346.
The goal of this study was to quantitatively assess the changes in the cerebral neurochemical profile and to identify those factors that contribute to the alteration of endogenous biomolecules when rats are subjected to stress-induced sleep disturbance. We exposed Sprague-Dawley rats (controls: n = 9; stress-induced sleep perturbation rats: n = 11) to a psychological stressor (cage exchange method) to achieve stress-induced sleep perturbation. In vivo magnetic resonance imaging assessments were carried out using a high-resolution 9.4 T system. For in vivo neurochemical analysis, a single voxel was localized in the right dorsal hippocampal region, and in vivo spectra were quantified for 17 cerebral neurochemical signals. Rats were sacrificed upon completion of the magnetic resonance spectroscopy protocol, and whole-brain tissue was harvested from twenty subjects. The dopamine and serotonin signals were obtained by performing in vitro liquid chromatography-tandem mass spectrometry on the harvested tissue.
3.Orientation-Selective Alignments of Hydroxyapatite Nanoblocks through Epitaxial Attachment in a and c Directions.
Nakamura K1, Nakagawa Y1, Kageyama H1, Oaki Y1, Imai H1. Langmuir. 2016 Apr 14. [Epub ahead of print]
Nanometric rods of hydroxyapatite (HA) were aligned in selective crystallographic directions by the alternation of adsorbing molecules. The side and end faces of HA nanorods elongated in the c direction were covered with oleic acid (OA) and tetraoctylammonium (TOA) ions, respectively. Alignment in the c direction of the OA-modified nanorods was produced through epitaxial attachment of the bare end faces in toluene because the side faces were hydrophobized with the negatively charged modifier. Another alignment-in the a direction of the TOA-modified HA nanorods-was obtained through the epitaxial attachment of the bare side faces in ethanol due to stabilization of the end faces with the positively charged modifier. Controlled alignments of the nanorods in the a and c directions were achieved through oriented attachment with the selective coverage of the c and a faces with the specific modifiers.
4.Serum Uric Acid Is Positively Associated with Handgrip Strength among Japanese Community-Dwelling Elderly Women.
Kawamoto R1,2, Ninomiya D1,2, Kasai Y2, Kusunoki T2, Ohtsuka N2, Kumagi T1, Abe M1. PLoS One. 2016 Apr 14;11(4):e0151044. doi: 10.1371/journal.pone.0151044.
Serum uric acid (UA) has strong anti-oxidant properties. Muscle strength and mass decrease with age, and recently, this decrease has been defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether serum UA is associated with handgrip strength (HGS), which is a useful indicator of sarcopenia, among Japanese community-dwelling elderly persons. The present study included 602 men aged 72 ± 7 years and 847 women aged 71 ± 6 years from a rural village. We examined the cross-sectional relationship between serum UA and HGS. In both genders, HGS increased significantly with increased serum UA levels. A multiple linear regression analysis using HGS as an objective variable and various confounding factors as explanatory variables showed that in men age, drinking status, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and estimated glomerular filtration ratio (eGFRCKDEPI) were independently and significantly associated with HGS, and in women, serum UA as well as age, body mass index, drinking status, diastolic blood pressure, and eGFRCKDEPI were independently and significantly associated with HGS.
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Chemical Structure

CAS 128796-39-4 4-Trifluoromethylphenylboronic acid

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