|Description||4-Phenyl-2-pyrrolidone-1-acetamide is a GABA derivative that exhibited apparent immunocorrection properties during immunosuppression induced by cyclophosphamide. It is used as a stimulant nootropic drug which can be up to 30-60 times more potent than piracetam. It may have anti-amnesic, antidepressant, anticonvulsant, antipsychotic, anxiolytic, and memory enhancement effects. It has been evaluated for its efficacy in reducing neurological deficits related to cerebral ischemia, epilepsy, and neurobehavioral disorders. At 10-100 mg/kg in mice, it can increase locomotor and antidepressant activity in the open-field and forced swimming tests, and can enhance memory in a passive avoidance response test. It was developed in 1983 in Russia. It has been listed as a banned substance by the World Anti-Doping Agency and the International Olympic Committee because of its cognitive enhancing and general stimulant properties. It is intended for research and forensic purposes only.|
|Appearance||Pale Yellow Solid|
|Solubility||10 mM in DMSO|
|Application||4-Phenyl-2-pyrrolidone-1-acetamide is used as a stimulant nootropic drug which can be up to 30-60 times more potent than piracetam. It may have anti-amnesic, antidepressant, anticonvulsant, antipsychotic, anxiolytic, and memory enhancement effects. It has been evaluated for its efficacy in reducing neurological deficits related to cerebral ischemia, epilepsy, and neurobehavioral disorders. It is intended for research and forensic purposes only.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Kilogram to ton|
|Boiling Point||486.4±45.0 °C | Condition: Press: 760 Torr|
|Melting Point||129.5-130.5 °C | Condition: Solv: ethyl acetate (141-78-6)|
|Density||1.220±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||It has been approved the listing.|
Potent and selective AMPA antagonist.
UBP 282 is an AMPA and kainate receptor antagonist. UBP 282 inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons y...
ZK200775 hydrate(Fanapanel; MPQX) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 &mu...
CX 614 has been found to be an AMPA modulator and has also been found to be an ampakine drug facilitating activation of glutamatergic AMPA receptors.
4-Phenyl-2-pyrrolidone-1-acetamide is a GABA derivative that exhibited apparent immunocorrection properties during immunosuppression induced by cyclophosphamide...
IDRA-21, an analog of cyclothiazide, inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 inhibits synaptic and extrasy...
(R)-AMPA is an inactive enantiomer of AMPA, which has been found to be a definitive agonist of the AMPA glutamatergic ionotropic receptor.
GYKI-53405 is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) antagonist. It can bind to Xenopus brain membranes ...