4-Phenyl-2-pyrrolidone-1-acetamide - CAS 77472-70-9
Catalog number: 77472-70-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C12H14N2O2
Molecular Weight:
218.25
COA:
Inquire
Targets:
AMPAR
Description:
4-Phenyl-2-pyrrolidone-1-acetamide is a GABA derivative that exhibited apparent immunocorrection properties during immunosuppression induced by cyclophosphamide. It is used as a stimulant nootropic drug which can be up to 30-60 times more potent than piracetam. It may have anti-amnesic, antidepressant, anticonvulsant, antipsychotic, anxiolytic, and memory enhancement effects. It has been evaluated for its efficacy in reducing neurological deficits related to cerebral ischemia, epilepsy, and neurobehavioral disorders. At 10-100 mg/kg in mice, it can increase locomotor and antidepressant activity in the open-field and forced swimming tests, and can enhance memory in a passive avoidance response test. It was developed in 1983 in Russia. It has been listed as a banned substance by the World Anti-Doping Agency and the International Olympic Committee because of its cognitive enhancing and general stimulant properties. It is intended for research and forensic purposes only.
Purity:
>98%
Appearance:
Pale Yellow Solid
Synonyms:
2-(2-Oxo-4-phenyl-pyrrolidin-1-yl)acetamide;Carphedon;4-phenylpiracetam;2-Oxo-4-phenyl-1-pyrrolidineacetamide;2-Oxo-4-phenylpyrrolidine-1-acetamide;2-(2-keto-4-phenyl-pyrrolidin-1-yl)acetamide;Phenylpiracetam;Karfedon
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
4-Phenyl-2-pyrrolidone-1-acetamide is used as a stimulant nootropic drug which can be up to 30-60 times more potent than piracetam. It may have anti-amnesic, antidepressant, anticonvulsant, antipsychotic, anxiolytic, and memory enhancement effects. It has been evaluated for its efficacy in reducing neurological deficits related to cerebral ischemia, epilepsy, and neurobehavioral disorders. It is intended for research and forensic purposes only.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Kilogram to ton
Boiling Point:
486.4±45.0 °C | Condition: Press: 760 Torr
Melting Point:
129.5-130.5 °C | Condition: Solv: ethyl acetate (141-78-6)
Density:
1.220±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
LYONXVJRBWWGQO-UHFFFAOYSA-N
InChI:
InChI=1S/C12H14N2O2/c13-11(15)8-14-7-10(6-12(14)16)9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,13,15)
Canonical SMILES:
C1C(CN(C1=O)CC(=O)N)C2=CC=CC=C2
Current Developer:
It has been approved the listing.
1.Prevalence of illicit drug use among the Italian athlete population with special attention on drugs of abuse: a 10-year review.
Strano Rossi S;Botrè F J Sports Sci. 2011 Mar;29(5):471-6. doi: 10.1080/02640414.2010.543915.
The objective of this study was to assess the prevalence of illicit drugs use among young adults, in particular elite athletes. This study considers the data obtained from anti-doping analyses performed on nearly 100,000 urine samples from 2000 to 2009 by the World Anti-Doping Agency accredited Italian Anti-Doping Laboratory. The percentage of adverse analytical findings varies on a yearly basis, but it is in the range 1.0-1.8% (not considering atypical findings, such as an altered endogenous steroid profile). Among positive results, there is a high prevalence of stimulants and drugs of abuse. The drug of abuse found most frequently is the tetrahydrocannabinol (cannabis) metabolite, accounting for 0.2-0.4% of the total samples analysed (18% of the positive results). The second most frequently encountered drug is cocaine, as detected from cocaine metabolites, accounting for 0.1% of the total samples analysed (7% of positive results). Other stimulants found included amphetamines, ephedrines, carphedon, modafinil, and anorexic compounds. No amphetamine-like designer drugs were detected. These data are indicative of the widespread prevalence of cocaine and cannabis use among the young adult population.
2.[Use of stimulants and drugs of abuse in sport: the Italian experience].
Strano Rossi S;Abate MG;Braganò MC;Botrè F Adicciones. 2009;21(3):239-42.
The incidence of the abuse of illicit drugs in sport may be a useful indicator of the extent of the phenomenon among the youth population. Many drugs of abuse are included in the WADA (World Anti-Doping Agency) Prohibited List, and are therefore routinely tested for in antidoping controls. This study presents the data obtained in tests carried out in the period 2003- 2007 at the Antidoping Laboratory of Rome, on 44781 samples analysed. The methods used are those developed by the Laboratory for routine antidoping analyses. The percentage of positive test results ranges from 1.1 to 2%, with a high incidence of stimulants and drugs of abuse. The substance most frequently found is THC metabolite, which accounts for 0.2-0.4% of the total, followed by cocaine metabolites, accounting for 0.1%. Other stimulants found are ephedrines, carphedon, modafinil, and anorexic compounds such as phendimetrazine and norfenfluramine. No amphetamines or amphetaminelike designer drugs have been detected. These data may be indicative of the widespread incidence of cocaine and cannabis abuse among the young Italian population, bearing in mind that the phenomenon is underestimated in this study, due to the fact that drugs of abuse are investigated only in samples involved in competitive sport, and especially to the fact that people doing such activities take more care of their health and are subject to greater control in their behaviour and habits with respect to the 'normal' population.
3.[Pharmacological characteristics of a new phenyl analog of piracetam--4-phenylpiracetam].
Bobkov IuG;Morozov IS;Glozman OM;Nerobkova LN;Zhmurenko LA Biull Eksp Biol Med. 1983 Apr;95(4):50-3.
The central neurotropic effects of 4-phenylpyracetam, a new phenyl analog of pyracetam, were studied and compared with the effects of pyracetam, morpholene and 4-phenylpyrrolidone. 4-Phenylpyracetam was found to activate the operant behavior more powerfully, to remove psychodepressant effects of diazepam, to inhibit post-rotational nystagmus, and to prevent the development of retrograde amnesia. Unlike pyracetam, 4-phenylpyracetam exhibits a specific anticonvulsant action. When given in high doses, the compound under study produces psychodepressant effects.
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CAS 77472-70-9 4-Phenyl-2-pyrrolidone-1-acetamide

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