4-Hydroxybenzaldehyde - CAS 123-08-0
Catalog number: 123-08-0
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Molecular Formula:
C7H6O2
Molecular Weight:
122.1
COA:
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Chemical Family:
Phenols
Description:
4-Hydroxybenzaldehyde comes from the herb of Gastrodia elata Blume, it shows an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant.
Purity:
0.98
Appearance:
Powder
Synonyms:
p-Hydroxybenzaldehyde
MSDS:
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Application:
antiepileptic and anticonvulsive activity
Quality Standard:
Enterprise Standard
Quantity:
Grams-Kilograms
Density:
1,129 g/cm3
1.4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes.
Kang CW;Han YE;Kim J;Oh JH;Cho YH;Lee EJ Sci Rep. 2017 Oct 27;7(1):14192. doi: 10.1038/s41598-017-14368-y.
4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and re-epithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway.
2.Metabolism of aromatic aldehydes as cosubstrates by the acetogen Clostridium formicoaceticum.
Frank C;Schwarz U;Matthies C;Drake HL Arch Microbiol. 1998 Nov;170(6):427-34.
When the acetogen Clostridium formicoaceticum was cultivated on mixtures of aromatic compounds (e.g., 4-hydroxybenzaldehyde plus vanillate), the oxidation of aromatic aldehyde groups occurred more rapidly than did O-demethylation. Likewise, when fructose and 4-hydroxybenzaldehyde were simultaneously provided as growth substrates, fructose was utilized only after the aromatic aldehyde group was oxidized to the carboxyl level. Aromatic aldehyde oxidoreductase activity was constitutive (activities approximated 0. 8 U mg-1), and when pulses of 4-hydroxybenzaldehyde were added during fructose-dependent growth, the rate at which fructose was utilized decreased until 4-hydroxybenzaldehyde was consumed. Although 4-hydroxybenzaldehyde inhibited the capacity of cells to metabolize fructose, lactate or gluconate were consumed simultaneously with 4-hydroxybenzaldehyde, and lactate or aromatic compounds lacking an aldehyde group were utilized concomitantly with fructose.
3.Copper and manganese: two concordant partners in the catalytic oxidation of p-cresol to p-hydroxybenzaldehyde.
Wang F;Yang GY;Zhang W;Wu WH;Xu J Chem Commun (Camb). 2003 May 21;(10):1172-3.
Copper and manganese were found to be two concordant partners in the synthesis of p-hydroxybenzaldehyde from p-cresol; under mild conditions, this research realised 95.6% selectivity for p-hydroxybenzaldehyde at 98.5% conversion of p-cresol.
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CAS 123-08-0 4-Hydroxybenzaldehyde

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