4-Hydroxybenzaldehyde - CAS 123-08-0
Catalog number: 123-08-0
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Chemical Family:
4-Hydroxybenzaldehyde comes from the herb of Gastrodia elata Blume, it shows an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant.
antiepileptic and anticonvulsive activity
Quality Standard:
Enterprise Standard
1,129 g/cm3
1.4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes.
Kang CW;Han YE;Kim J;Oh JH;Cho YH;Lee EJ Sci Rep. 2017 Oct 27;7(1):14192. doi: 10.1038/s41598-017-14368-y.
4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and re-epithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway.
2.Metabolism of aromatic aldehydes as cosubstrates by the acetogen Clostridium formicoaceticum.
Frank C;Schwarz U;Matthies C;Drake HL Arch Microbiol. 1998 Nov;170(6):427-34.
When the acetogen Clostridium formicoaceticum was cultivated on mixtures of aromatic compounds (e.g., 4-hydroxybenzaldehyde plus vanillate), the oxidation of aromatic aldehyde groups occurred more rapidly than did O-demethylation. Likewise, when fructose and 4-hydroxybenzaldehyde were simultaneously provided as growth substrates, fructose was utilized only after the aromatic aldehyde group was oxidized to the carboxyl level. Aromatic aldehyde oxidoreductase activity was constitutive (activities approximated 0. 8 U mg-1), and when pulses of 4-hydroxybenzaldehyde were added during fructose-dependent growth, the rate at which fructose was utilized decreased until 4-hydroxybenzaldehyde was consumed. Although 4-hydroxybenzaldehyde inhibited the capacity of cells to metabolize fructose, lactate or gluconate were consumed simultaneously with 4-hydroxybenzaldehyde, and lactate or aromatic compounds lacking an aldehyde group were utilized concomitantly with fructose.
3.Copper and manganese: two concordant partners in the catalytic oxidation of p-cresol to p-hydroxybenzaldehyde.
Wang F;Yang GY;Zhang W;Wu WH;Xu J Chem Commun (Camb). 2003 May 21;(10):1172-3.
Copper and manganese were found to be two concordant partners in the synthesis of p-hydroxybenzaldehyde from p-cresol; under mild conditions, this research realised 95.6% selectivity for p-hydroxybenzaldehyde at 98.5% conversion of p-cresol.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Phenols Products

CAS 127757-13-5 2'-O-Methylbroussonin A

2'-O-Methylbroussonin A
(CAS: 127757-13-5)

2'-O-Methylbroussonin A is isolated from the branches of Broussonetia papyrifera.

CAS 147821-49-6 Niazimicin

(CAS: 147821-49-6)

Niazimicin is a natural compound isolated from the seeds of Moringa oleifera, showing antimicrobial activity.

CAS 136133-08-9 3,7-Di-O-methylducheside A

3,7-Di-O-methylducheside A
(CAS: 136133-08-9)

3,7-Di-O-methylducheside A is purified from the roots of Diplopanax stachyanthus.

CAS 2033-89-8 3,4-Dimethoxyphenol

(CAS: 2033-89-8)

3,4-Dimethoxyphenol is a natural phenol found in the herbs of Tripterygium wilfordii.

CAS 64432-04-8 Grifolin monomethyl ether

Grifolin monomethyl ether
(CAS: 64432-04-8)

Grifolin monomethyl ether is a natural compound isolated from the fresh fruiting bodies of Albatrellus confluens.

CAS 85643-19-2 Curculigoside

(CAS: 85643-19-2)

Curculigoside, isolated from the rhizomes of Curculigo orchioides Gaertn, improved osteogenesis and inhibited osteoclastogenesis of hAFSCs, suggesting its poten...

(CAS: 56973-51-4)

Alnusdiol isolated from the barks of Alnus japonica.

CAS 156-38-7 4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid
(CAS: 156-38-7)

4-Hydroxyphenylacetic acid is a phenolic compound found in olive oil and beer. In industry 4-Hydroxyphenylacetic acid is an intermediate used to synthesize aten...

Chemical Structure

CAS 123-08-0 4-Hydroxybenzaldehyde

Quick Inquiry

Verification code

Featured Items